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Inhibition of full length GST tagged mouse wild type B-Raf preincubated for 1 hr and measured after 25 mins in presence of ATP
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
SummaryRelated BioAssays by Target
Inhibition of mouse full length GST-tagged BRAF V600E mutant using recombinant human His6-tagged MEK1 as substrate preincubated for 1 hr followed by substrate addition measured after 25 mins by ELISA
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of mouse full length GST-tagged BRAF V600E mutant using recombinant human full length N-terminal His-tagged MEK1 as substrate preincubated for 1 hr followed by substrate addition measured after 25 mins
Assay data:6 Active, 5 Activity ≤ 1 µM, 17 Tested
Induction of N-terminal 6x-His-tagged BRAF R509H/W450A mutant (unknown origin) dimer formation assessed as molecular weight of protein-compound complex at 20 uM by sedimentation equilibrium method
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Induction of N-terminal 6x-His-tagged BRAF R509H/R506A mutant (unknown origin) dimer formation assessed as molecular weight of protein-compound complex at 20 uM by sedimentation equilibrium method
Induction of N-terminal 6x-His-tagged BRAF V600E/R509H mutant (unknown origin) dimer formation at 12 uM by sedimentation velocity method
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of mouse full length GST-tagged BRAF V600E mutant using recombinant human full length N-terminal His-tagged MEK1 as substrate preincubated for 1 hr followed by substrate addition measured after 25 mins by Nu-page gel-based phosphor screen analysis
Assay data:21 Active, 5 Activity ≤ 1 µM, 21 Tested
Inhibition of mouse full-length GST-tagged BRAF V600E mutant using recombinant human full length N-terminal His-tagged MEK1 as substrate preincubated for 60 mins followed by substrate addition and measured after 25 mins by ELISA
Assay data:7 Active, 5 Activity ≤ 1 µM, 7 Tested
Inhibition of full-length GST-tagged mouse BRAF V600E mutant using recombinant human full length N-terminal His-tagged MEK1 as substrate preincubated for 1 hr followed by substrate addition measured after 25 mins by Nu-page gel-based phosphor screen analysis
Assay data:25 Active, 13 Activity ≤ 1 µM, 25 Tested
Inhibition of mouse wild type BRAF assessed as reduction in human full length N-terminal His-tagged MEK1 phosphorylation pre-incubated for 1 hr before MEK1 addition and measured after 25 mins
Assay data:6 Active, 1 Activity ≤ 1 µM, 6 Tested
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen NFkB readout
Assay data:762 Active, 16821 Tested
SummaryRelated BioAssays by Same Project
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen TNF readout
Assay data:1106 Active, 16821 Tested
A screen to identify the genes that modify the response of osteosarcoma to doxorubicin in mouse - Primary Screen
Assay data:788 Active, 16789 Tested
SummaryPubMed Citation
Inhibition of wild type BRAF in mouse NIH/3T3 cells assessed as decrease in ERK phosphorylation after 75 mins by Western blotting analysis
Assay data:1 Active, 2 Tested
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