BioAssay by Target (List) for Gene (Select 11011) - PubChem BioAssay - NCBI

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Select item 19046791.

Inhibition of TLK2 (unknown origin)

Source:: ChEMBL

Protein Target:: Serine/threonine-protein kinase tousled-like 2

Assay data:1 Active, 1 Tested

AID:: 1904679

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 18879632.

Binding affinity to full length FLAG/HA/Strep-tagged TLK2 (388 to 772 residues) (unknown origin) transfected in HEK293T cells by Alexa Fluor 647 staining based FRET assay

Source:: ChEMBL

Protein Target:: Serine/threonine-protein kinase tousled-like 2

Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested

AID:: 1887963

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 18879613.

Inhibition of full length FLAG/HA/Strep-tagged TLK2 (unknown origin) transfected in HEK293T cells assessed as reduction in ASF1a phosphorylation at S166 residue at 5 uM by Western blot analysis

Source:: ChEMBL

Protein Target:: Serine/threonine-protein kinase tousled-like 2

Assay data:5 Active, 5 Tested

AID:: 1887961

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 18879504.

Inhibition of full length FLAG/HA/Strep-tagged TLK2 (unknown origin) in human MDA-MB-231 cells assessed as reduction in ASF1 phosphorylation at 16.7 uM measured after 4 hrs by Western blot analysis

Source:: ChEMBL

Protein Target:: Serine/threonine-protein kinase tousled-like 2

Assay data:1 Active, 1 Tested

AID:: 1887950

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 18879495.

Inhibition of full length FLAG/HA/Strep-tagged TLK2 (unknown origin) in human U2OS cells assessed as ASF1 phosphorylation by measuring decrease in band shift at 16.7 uM measured after 4 hrs by Western blot analysis

Source:: ChEMBL

Protein Target:: Serine/threonine-protein kinase tousled-like 2

Assay data:1 Active, 1 Tested

AID:: 1887949

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 18879486.

Inhibition of full length FLAG/HA/Strep-tagged TLK2 (unknown origin) in human U2OS cells assessed as reduction in ASF1 phosphorylation at 16.7 uM measured after 4 hrs by Western blot analysis

Source:: ChEMBL

Protein Target:: Serine/threonine-protein kinase tousled-like 2

Assay data:1 Active, 1 Tested

AID:: 1887948

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 18879477.

Inhibition of full length FLAG/HA/Strep-tagged TLK2 (unknown origin) transfected in HEK293T cells assessed as reduction in TLK mediated ASF1a phosphorylation at 50 uM by Western blot analysis

Source:: ChEMBL

Protein Target:: Serine/threonine-protein kinase tousled-like 2

Assay data:1 Active, 2 Tested

AID:: 1887947

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 18879468.

Inhibition of full length FLAG/HA/Strep-tagged TLK2 (unknown origin) transfected in HEK293T cells at 50 uM using GST-ASF1 as substrate preincubated for 15 mins followed by substrate addition and measured after 15 mins in presence of ATP by Western blot analysis

Source:: ChEMBL

Protein Target:: Serine/threonine-protein kinase tousled-like 2

Assay data:3 Active, 3 Tested

AID:: 1887946

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 18356269.

TLK2 DiscoveRx kinase panel

Source:: ChEMBL

Protein Target:: Serine/threonine-protein kinase tousled-like 2

Assay data:1 Tested

AID:: 1835626

Summary Related BioAssays by Target

Select item 183518310.

TLK2(h) Kinase panel

Source:: ChEMBL

Protein Target:: Serine/threonine-protein kinase tousled-like 2

Assay data:1 Tested

AID:: 1835183

Summary Related BioAssays by Target

Select item 183435311.

Inhibition of TLK2 (unknown origin) at 1 uM

Source:: ChEMBL

Protein Target:: Serine/threonine-protein kinase tousled-like 2

Assay data:1 Tested

AID:: 1834353

Summary PubMed Citation Related BioAssays by Target

Select item 182009612.

Inhibition of TLK2 (unknown origin) assessed as residual activity at 1 uM

Source:: ChEMBL

Protein Target:: Serine/threonine-protein kinase tousled-like 2

Assay data:1 Active, 1 Tested

AID:: 1820096

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 179436713.

KinomeScan assay: inhibition of TLK2

Source:: ChEMBL

Protein Target:: Serine/threonine-protein kinase tousled-like 2

Assay data:108 Tested

AID:: 1794367

Summary Related BioAssays by Target

Select item 179286914.

TLK2(h) Eurofins kinase panel

Source:: ChEMBL

Protein Target:: Serine/threonine-protein kinase tousled-like 2

Assay data:1 Tested

AID:: 1792869

Summary Related BioAssays by Target

Select item 178948515.

TLK2(h) Eurofins Kinase panel

Source:: ChEMBL

Protein Target:: Serine/threonine-protein kinase tousled-like 2

Assay data:1 Tested

AID:: 1789485

Summary Related BioAssays by Target

Select item 178913516.

TLK2 (h) Millipore kinase activity assay

Source:: ChEMBL

Protein Target:: Serine/threonine-protein kinase tousled-like 2

Assay data:1 Tested

AID:: 1789135

Summary Related BioAssays by Target

Select item 178754117.

TLK2(h) Millipore kinase panel

Source:: ChEMBL

Protein Target:: Serine/threonine-protein kinase tousled-like 2

Assay data:1 Tested

AID:: 1787541

Summary Related BioAssays by Target

Select item 178629718.

TLK2 Invitrogen Lab (UK) kinase screen (BI)

Source:: ChEMBL

Protein Target:: Serine/threonine-protein kinase tousled-like 2

Assay data:1 Tested

AID:: 1786297

Summary Related BioAssays by Target

Select item 177986219.

Inhibition of NanoLuc-fused TLK2 (unknown origin) expressed in HEK293T cells after 2 hrs by NanoBRET assay

Source:: ChEMBL

Protein Target:: Serine/threonine-protein kinase tousled-like 2

Assay data:2 Tested

AID:: 1779862

Summary PubMed Citation Related BioAssays by Target

Select item 177985120.

Inhibition of wild-type human partial length TLK2 (E424 to N749 residues) expressed in bacterial expression system assessed as residual percent of control by Kinomescan method relative to control

Source:: ChEMBL

Protein Target:: Serine/threonine-protein kinase tousled-like 2

Assay data:2 Tested

AID:: 1779851

Summary PubMed Citation Related BioAssays by Target

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Target

Proteins (2)
BioAssays with protein sequences specified as targets
RNAi Target, Active (8)
BioAssays with gene sequences specified as RNAi targets and the activity is active

BioActivity

Active Compounds (17)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (1)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (7)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Summary (2)
BioAssays summarizing information from multiple assays for validated chemical probes or small molecule leads
Confirmatory (14)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
Primary Screening (40)
Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose
Chemical Screens (94)
BioAssays reporting BioActivity of chemical reagents
RNAi Screens (45)
BioAssays reporting BioActivity of RNAi reagents

Assay Project (2)
BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

Depositor Category

Literature Extraction (77)
BioAssays extracted from the literature
NIH MLP (2)
BioAssays deposited by the NIH Molecular Libraries Program
Other (59)
BioAssays deposited by other experimentalists

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BioAssay by Target (List) for Gene (Select 11011) (139)
PubChem BioAssay
serine/threonine-protein kinase tousled-like 2 isoform X8 [Homo sapiens]
serine/threonine-protein kinase tousled-like 2 isoform X8 [Homo sapiens]
gi|2462552546|ref|XP_054170762.1|

Protein

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