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Inhibition of 17beta-HSD3 in Sprague-Dawley rat testes microsomal fraction assessed as reduction in [14C]-testosterone formation from [14C]-4-androstene-3,17-dione measured after 2 hrs
Assay data:5 Active, 5 Activity ≤ 1 µM, 5 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Ratio of delta4-dione IC50 to compound IC50 for 17beta-HSD3 in rat testes microsomes
Assay data:2 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of 17beta-HSD3 in rat testes microsomes using [14C]-4-androstene-3,17-dione as substrate after 2 hrs
Inhibition of 17beta-HSD3 in rat testes microsomes using [14C]-4-androstene-3,17-dione as substrate measured based on 18% of initial enzyme transformation at 0.01 uM after 2 hrs
Assay data:17 Tested
Inhibition of 17beta-HSD3 in rat testes microsomes using [14C]-4-androstene-3,17-dione as substrate measured based on 33% of initial enzyme transformation at 10 uM after 2 hrs
Assay data:13 Tested
Inhibition of 17beta-HSD3 in rat testes microsomes using [14C]-4-androstene-3,17-dione as substrate measured based on 33% of initial enzyme transformation at 1 uM after 2 hrs
Inhibition of 17beta-HSD3 in rat testes microsomes using [14C]-4-androstene-3,17-dione as substrate measured based on 33% of initial enzyme transformation at 0.1 uM after 2 hrs
Inhibition of 17beta-HSD3 in rat testes microsomes using [14C]-4-androstene-3,17-dione as substrate measured based on 4% of initial enzyme transformation at 10 uM after 2 hrs
Inhibition of 17beta-HSD3 in rat testes microsomes using [14C]-4-androstene-3,17-dione as substrate measured based on 4% of initial enzyme transformation at 1 uM after 2 hrs
Inhibition of 17beta-HSD3 in rat testes microsomes using [14C]-4-androstene-3,17-dione as substrate measured based on 18% of initial enzyme transformation at 1 uM after 2 hrs
Assay data:25 Tested
Inhibition of 17beta-HSD3 in rat testes microsomes using [14C]-4-androstene-3,17-dione as substrate measured based on 18% of initial enzyme transformation at 0.1 uM after 2 hrs
Assay data:32 Tested
Inhibition of 17beta-HSD3 in rat testes microsomal fraction using [14C]-4-androstene-3,17-dione as substrate assessed as testosterone formation at 0.1 uM after 2 hrs by thin layer chromatography
Assay data:7 Tested
Inhibition of 17beta-HSD3 in rat testes microsomal fraction using [14C]-4-androstene-3,17-dione as substrate assessed as testosterone formation at 1 uM after 2 hrs by thin layer chromatography
Inhibition of 17beta-HSD3 in rat testes microsomal fraction using [14C]-4-androstene-3,17-dione as substrate assessed as testosterone formation after 2 hrs by thin layer chromatography
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
Uncompetitive inhibition of 17beta-HSD3 in Sprague-Dawley rat testis microsomes at 1 to 10 uM by Lineweaver-Burke plot analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of 17beta-HSD3 in Sprague-Dawley rat testis microsomes
Assay data:5 Active, 1 Activity ≤ 1 µM, 5 Tested
Inhibition of 17beta-HSD3 in Sprague-Dawley rat testis microsomes at 100 uM
Assay data:23 Tested
Inhibition of 17beta-HSD3 in Sprague-Dawley rat laydig cells
Assay data:4 Active, 2 Activity ≤ 1 µM, 5 Tested
Inhibition of 17beta-HSD3 in Sprague-Dawley rat laydig cells at 100 uM
Assay data:22 Tested
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