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TPK assay from Article 10.1016/0960-894X(94)00458-R: "Novel Indolocarbazole protein kinase C inhibitors with improved biochemical and physicochemical properties."
Assay data:1 Active, 1 Activity ≤ 1 µM, 8 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Inhibition of mouse BLK assessed as remaining enzyme activity at 0.01 uM
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of mouse BLK assessed as remaining enzyme activity at 0.1 uM
Inhibition of mouse BLK assessed as remaining enzyme activity at 1 uM
Inhibition of recombinant full length mouse BLK assessed as residual activity at 10 uM using poly(Glu, Tyr) 4:1 as substrate incubated for 40 mins in presence of [gamma-33ATP] by scintillation counting based radiometry assay relative to control
Inhibition of recombinant full-length mouse Blk at 1 uM using poly(Glu,Tyr) 4:1 as substrate after 40 mins in presence of [gamma-33P]ATP by scintillation counting method
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen NFkB readout
Assay data:762 Active, 16821 Tested
SummaryRelated BioAssays by Same Project
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen TNF readout
Assay data:1106 Active, 16821 Tested
Inhibition of mouse Blk assessed as residual activity at 1 uM relative to control
A screen to identify the genes that modify the response of osteosarcoma to doxorubicin in mouse - Primary Screen
Assay data:788 Active, 16789 Tested
SummaryPubMed Citation
Inhibition of mouse BLK using ATP as substrate
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of mouse Blk at 10 uM after 60 mins by TR-FRET assay
Inhibition of mouse BLK
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Activity of mouse Blk kinase at 1 uM
Inhibition of mouse Blk at 1 uM relative to control
Assay data:4 Tested
Percentage activity of mouse Blk in the presence of 10 uM of compound and 10 uM of ATP in comparison with control
Residual activity at mouse Blk at 10 uM in presence of 10 uM ATP relative to control
Tested for inhibition of general tyrosine-specific protein kinase activity from murine B cell lysate; not determined
Assay data:12 Tested
SummaryRelated BioAssays by Target
Tested for inhibition of general tyrosine-specific protein kinase activity from murine B cell lysate
Assay data:1 Active, 1 Activity ≤ 1 µM, 6 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition of B lymphoid tyrosine kinase
Assay data:3 Tested
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