Warning: The NCBI web site requires JavaScript to function. more...
An official website of the United States government
The .gov means it's official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.
The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.
Selectivity interaction (Serine protease panel) EUB0000735a CMA1
Assay data:1 Tested
SummaryRelated BioAssays by Target
Binding affinity to human mast cell chymase assessed as inhibition constant using Succinyl-L-alanyl-L-alanyl-L-prolyl-L phenylalanine p-Nitroaniline as substrate measured upto 120 mins by spectrophotometric analysis
SummaryPubMed CitationRelated BioAssays by Target
In Vitro Assay from US Patent US8969348: "Chymase inhibitors"
Assay data:10 Active, 10 Activity ≤ 1 µM, 10 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibitory Assay from US Patent US8846660: "Seven-membered ring compound and pharmaceutical use therefor"
Assay data:29 Active, 29 Activity ≤ 1 µM, 29 Tested
Inhibition Assay from US Patent US8507714: "7-membered ring compound and method of production and pharmaceutical application thereof"
Assay data:17 Active, 14 Activity ≤ 1 µM, 17 Tested
In Vitro Assay from US Patent US8501749: "Azaquinazolinediones chymase inhibitors"
Assay data:31 Active, 5 Activity ≤ 1 nM, 31 Activity ≤ 1 µM, 31 Tested
Enzyme Inhibition Assay from Article 10.1080/14756360310001650200: "Design and synthesis of indole and tetrahydroisoquinoline hydantoin derivatives as human chymase inhibitors."
Assay data:11 Tested
Enzyme Inhibition Assay from Article 10.1038/35422: "Design of potent selective zinc-mediated serine protease inhibitors."
Assay data:9 Active, 1 Activity ≤ 1 nM, 8 Activity ≤ 1 µM, 9 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Enzymatic Assay from US Patent US9751843: "Substituted uracils and use thereof"
Assay data:148 Active, 143 Activity ≤ 1 µM, 148 Tested
Chymase (h) Protease assay
Chymase (h) Eurofins-Cerep enzyme and uptake assay
CHYMASE Eurofins SafetyScreen44 (BI)
Assay data:1 Active, 1 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Angiotensin II formation by CMA1 in human plasma
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of CMA1
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of chymase (unknown origin) at 10 uM relative to control
Inhibition of mammalian chymase (unknown origin) using Suc-AAPF-AMC as substrate preincubated for 10 mins followed by substrate addition measured after 30 mins
Binding affinity to recombinant human chymase expressed in Pichia pastoris X-33 cells assessed as change in enzyme structural characteristics by measuring secondary H-alpha chemical shifts by NMR spectroscopy
Assay data:5 Active, 5 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of recombinant human chymase expressed in Pichia pastoris X-33 cells assessed as decrease in angiotensin 1 cleavage to angiotensin 2 incubated for 120 mins at 298 K by UPLC-MS analysis
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
Inhibition of recombinant human chymase expressed in Pichia pastoris X-33 cells assessed as decrease in angiotensin 1 cleavage to angiotensin 2 at 50 nM incubated for 120 mins at 298 K by UPLC-MS analysis relative to control
Filters: Manage Filters
Your browsing activity is empty.
Activity recording is turned off.
Turn recording back on