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Antagonist activity at recombinant mouse CXCR3 expressed in human CHO-K1 cells co-expressing Galpha15 incubated for 10 mins by Fluo-4AM dye based FLIPR assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen NFkB readout
Assay data:762 Active, 16821 Tested
SummaryRelated BioAssays by Same Project
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen TNF readout
Assay data:1106 Active, 16821 Tested
A screen to identify the genes that modify the response of osteosarcoma to doxorubicin in mouse - Primary Screen
Assay data:788 Active, 16789 Tested
SummaryPubMed Citation
Receptor occupancy of CXCR3 in mouse whole blood assessed as inhibition of ITAC binding by fluorescence quenching based FACS analysis
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
Antagonist activity at mouse CXCR3 expressed in mouse L1.2 cells assessed as inhibition of ITAC-induced calcium mobilization by FLIPR assay
Assay data:34 Active, 33 Activity ≤ 1 µM, 34 Tested
Antagonist activity at mouse CXCR3
Assay data:4 Active, 1 Activity ≤ 1 nM, 4 Activity ≤ 1 µM, 4 Tested
Displacement of [125I]-IP10 from mouse CXCR3 expressed in human PBMC after 2 hrs in RPMI buffer by scintillation counting
Displacement of ITAC from CXCR3 receptor in mouse whole blood assay
Antagonist activity at mouse CXCR3 expressed in L1.2 cells assessed as inhibition of I-TAC-induced Ca2+ mobilization by FLIPR assay
Displacement of [125I]I-TAC from mouse CXCR3 expressed in CHO cells by scintillation proximity assay
Antagonist activity at mouse recombinant CXCR3 expressed in human U2OS cells
Assay data:13 Active, 8 Activity ≤ 1 µM, 13 Tested
Displacement of [125I]-CXCL10 from mouse CXCR3 expressed in CHO cell membrane
Assay data:13 Active, 9 Activity ≤ 1 µM, 13 Tested
Assay data:13 Active, 13 Activity ≤ 1 µM, 14 Tested
Antagonist activity at mouse CXCR3 by [35S]GTP-gamma-S binding assay
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