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SPR Assay from US Patent US11786528: "Pyrazolopyrimidine compounds as adenosine receptor antagonists"
Assay data:46 Active, 46 Activity ≤ 1 µM, 46 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Adenosine Receptor Time-Resolved Fluorescence Resonance Energy Transfer (TRFRET) Binding Assay from US Patent US20230293517: "ANTAGONIST COMPOUNDS"
Assay data:258 Active, 137 Activity ≤ 1 nM, 258 Activity ≤ 1 µM, 258 Tested
Binding Affinities to Different Adenosine Receptors from US Patent US11629147: "Triazolo-pyrimidine compounds and uses thereof"
Assay data:21 Active, 5 Activity ≤ 1 nM, 21 Activity ≤ 1 µM, 21 Tested
Selectivity interaction (CEREP panel (GPCRS, ion channels, transporters)) EUB0000193b ADORA3
Assay data:1 Active, 1 Tested
SummaryRelated BioAssays by Target
Assay data:1 Tested
Selectivity interaction (Eurofins-Panlabs radioligand binding assay ) EUB0000307b ADORA3
Selectivity interaction (CEREP panel (Eurofins, enzymes and uptake assays)) EUB0000544a ADORA3
Selectivity interaction (CEREP panel (Eurofins, binding assay)) EUB0000544a ADORA3
Selectivity interaction (Radioligand binding assay (MDS Pharma Service)) EUB0000296b ADORA3
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Selectivity interaction (CEREB panel (GPCRs, ion channels, and transporters)) EUB0000323b ADORA3
Selectivity interaction (NIBR principial panel (12 GPCRs, 3 nuclear receptors, 3 transporters, and 7 other enzymes)) EUB0000253b ADORA3
Selectivity interaction (CEREP panel (ligand receptors, ion channels, transporters)) EUB0000330a ADORA3
Selectivity interaction (Enzyme panel (Eurofins-Cerep)) EUB0000262b ADORA3
Selectivity interaction (CEREP panel (Eurofins, binding assay)) EUB0000262b ADORA3
Selectivity interaction (CEREP panel (human receptors, ion channels, enzymes)) EUB0000138c ADORA3
Inhibition of recombinant human adenosine A3 GPCR incubated for 120 mins by scintillation counting based radiometry assay
Assay data:2 Tested
SummaryPubMed CitationRelated BioAssays by Target
Displacement of [3H]HEMADO from human A3AR incubated for 60 mins by scintillation counter analysis
Assay data:3 Tested
Binding affinity towards human adenosine A3 receptor
Assay data:2 Active, 28 Activity ≤ 1 µM, 29 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Agonist activity at human adenosine A3A receptor stably expressed in HEK293 cells assessed as mini G-alpha recruitment maximum efficacy by luciferase based NanoBiT assay
Assay data:11 Tested
Agonist activity at human adenosine A3A receptor stably expressed in HEK293 cells assessed as mini G-alpha recruitment potency by luciferase based NanoBiT assay
Assay data:11 Active, 10 Activity ≤ 1 µM, 11 Tested
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