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Inhibition of human full length CSE using L-cysteine as substrate at 30 to 300 uM preincubated with enzyme for 1 hr followed by substrate and PLP addition for 2 hrs by AzMC probe based fluorescence analysis
Assay data:2 Active, 8 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Human CSE enzyme assay from Article 10.1021/cb500009r: "Novel inhibitors of human DOPA decarboxylase extracted from Euonymus glabra Roxb."
Assay data:14 Tested
SummaryPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
CSE In Vitro Assay from US Patent US10227314: "Cystathionine-gamma-lyase (CSE) inhibitors"
Assay data:13 Tested
SummaryRelated BioAssays by Target
In Vitro Assay from US Patent US9725426: "Cystathionine-γ-lyase (CSE) inhibitors"
Assay data:16 Active, 44 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Inhibition of human CSE using L-Cys as the substrate by tandem well based HTS assay
Assay data:3 Active, 1 Activity ≤ 1 µM, 27 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of human CSE using L-Cys as the substrate in presence of 0.025% Triton X-100 by tandem well based HTS assay
Assay data:3 Active, 3 Tested
Inhibition of human CSE using L-Cys as the substrate in presence of 0.01% Triton X-100 by tandem well based HTS assay
Inhibition of human CSE using H-Cys as the substrate by LC/MS/MS-based assay
Assay data:2 Active, 3 Tested
Inhibition of human CSE using H-Cys as the substrate by tandem well based HTS assay
Non-covalent reversible inhibition of human CSE
Assay data:2 Active, 2 Tested
Inhibition of human CSE by methylene blue method
Assay data:1 Active, 1 Tested
Binding affinity to human CSE by ITC analysis
Non-competitive inhibition of human CSE using varying levels of PLP and fixed L-Cys as substrate
Effect on PLP interaction with human CSE assessed as effect on spectra of CSE-bound PLP
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Competitive inhibition of human CSE using varying levels of L-Cys as substrate and fixed PLP levels
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
Inhibition of human CSE expressed in mouse RAW264.7 cells assessed as reduction in amount of released H2S level at 20 to 50 uM by lead acetate method
Inhibition of human CSE expressed in mouse RAW264.7 cells assessed as reduction in amount of released H2S level at >=200 uM by lead acetate method
Inhibition of wild type human CSE expressed in HEK293T cells assessed as reduction in H2S contents
Inhibition of human CSE R119A mutant expressed in HEK293T cells assessed as reduction in H2S contents
Inhibition of human CSE Y114F mutant expressed in HEK293T cells assessed as reduction in H2S contents
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