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In Vitro Enzymatic Cathepsin D (CatD) FRET Assay from US Patent US11548903: "Bicyclic thiazine and oxazine derivatives as beta-secretase inhibitors and methods of use"
Assay data:4 Active, 46 Tested
SummaryCompounds, ActiveRelated BioAssays by DepositorRelated BioAssays by Target
Inhibition of cathepsin D (unknown origin) using MCA labelled GKPILFFRLK(Dnp)-D-R-NH as substrate preincubated for 15 mins followed by substrate addition and measured after 2 hrs by fluorometer analysis
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of cathepsin D (unknown origin) using MCA labelled GKPILFFRLK(Dnp)-D-R-NH as substrate at 200 uM preincubated for 15 mins followed by substrate addition and measured after 2 hrs by fluorometer analysis
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of human liver cathepsin D at 100 uM using MOCAc-Gly-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Lys(Dnp)-D-Arg-NH2 as substrate preincubated for 15 mins followed by addition of substrate measured after 10 mins by measuring amount of MOCAc formed by spectrofluorimetric method
Inhibition of human liver cathepsin D using MOCAc-Gly-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Lys(Dnp)-D-Arg-NH2 as substrate preincubated for 15 mins followed by addition of substrate measured after 10 mins by measuring amount of MOCAc formed by spectrofluorimetric method
Inhibition of recombinant human liver Cathepsin D using Mca-Gly-Lys-Pro-Ile-Leu-Phe-Phe-Arg-Leu-Lys-(Dnp)-D-Arg-NH2 as substrate incubated for 120 mins by fluorescence assay
Assay data:10 Active, 3 Activity ≤ 1 nM, 10 Activity ≤ 1 µM, 10 Tested
Inhibition of human cathepsin D
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of Cathepsin D (unknown origin)
Inhibition of human Cathepsin D preincubated for 5 mins followed by substrate addition by fluorometer analysis
Assay data:5 Active, 3 Activity ≤ 1 µM, 6 Tested
Inhibition of human cathepsin D using Mca-GKPILFFRLK(DNP)D-R-NH2 as a substrate
Assay data:16 Tested
Inhibition of human Cathepsin D using Mca-GKPILFFRLK(DNP)D-R-NH2 as a substrate
Assay data:13 Tested
Inhibition of human cathepsin D assessed as inhibition constant using ACC-GKPILFFRILK-(DNP)-(dR)-NH2 as substrate by spectrophotometric analysis
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of human Cathepsin D by FRET assay
Inhibition of human cathepsin D incubated for 3.5 hrs by fluorescence assay
In Vitro Enzymatic Cathepsin D (CatD) FRET Assay from US Patent US11021493: "1,4-thiazine dioxide and 1,2,4-thiadiazine dioxide derivatives as beta-secretase inhibitors and methods of use"
Assay data:166 Tested
SummaryRelated BioAssays by DepositorRelated BioAssays by Target
In Vitro Enzymatic Cathepsin D (CatD) FRET Assay from US Patent US10947223: "Substituted oxazines as beta-secretase inhibitors"
Assay data:18 Tested
In Vitro Enzymatic FRET Assay from US Patent US10889581: "Cyclopropyl fused thiazine derivatives as beta-secretase inhibitors and methods of use"
Assay data:40 Tested
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