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Inhibition of CYP450 (unknown origin)
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of CYP1B1 (unknown origin)
Assay data:4 Active, 3 Activity ≤ 1 µM, 4 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of CYP1B1 (unknown origin) assessed as remaining enzyme activity relative to control
Assay data:4 Tested
Assay data:2 Tested
Metabolic stability of the compound in human liver microsomes assessed as CYP450-mediated metabolism by measuring parent compound remaining at 0.5 uM measured after 10 mins in presence of NADPH by LC-MS/MS analysis
Metabolic stability in human liver microsomes S9 fraction assessed as CYP450-mediated metabolism by measuring parent compound remaining measured after 60 mins in presence of NADPH
Metabolic stability in human liver microsomes S9 fraction assessed as CYP450-mediated metabolism by measuring parent compound remaining measured after 30 mins in presence of NADPH
Metabolic stability in human liver microsomes S9 fraction assessed as CYP450-mediated metabolism by measuring parent compound remaining measured after 15 mins in presence of NADPH
Induction of CYP450 (unknown origin)
Inhibition of CYP450 in human HCT-116 cells assessed as 20-HETE formation in presence of arachidonic acid incubated for 15 mins by multi-enzyme assay based LC-MS/MS analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of CYP450 in human HCT-116 cells assessed as 20-HETE formation in presence of arachidonic acid incubated for 15 mins by multi-enzyme assay based LC-MS/MS analysis relative to control
Inhibition of CYP450 in human liver microsomes assessed as inhibition of 20-HETE formation in presence of arachidonic acid and NADPH by multi-enzyme assay based LC-MS/MS analysis relative to control
Inhibition of CYP450 in human liver microsomes assessed as inhibition of 20-HETE formation in presence of arachidonic acid and NADPH by multi-enzyme assay based LC-MS/MS analysis
Inhibition of CYP450 in human liver microsomes assessed as inhibition of EpETrE formation at 10 uM in presence of arachidonic acid and NADPH by multi-enzyme assay based LC-MS/MS analysis relative to control
Assay data:31 Tested
Inhibition of CYP450 in human liver microsomes assessed as inhibition of 20-HETE formation at 10 uM in presence of arachidonic acid and NADPH by multi-enzyme assay based LC-MS/MS analysis relative to control
Metabolic stability assessed as P450 (unknown origin)-mediated biotransformation assessed as compound remaining measured after 120 mins
Metabolic stability assessed as P450 (unknown origin)-mediated biotransformation assessed as compound remaining measured after 15 mins
Drug metabolism in human hepatocytes assessed as fraction of Cyp mediated oxidative metabolism in presence of NADPH
Assay data:3 Tested
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