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Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen NFkB readout
Assay data:762 Active, 16821 Tested
SummaryRelated BioAssays by Same Project
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen TNF readout
Assay data:1106 Active, 16821 Tested
A screen to identify the genes that modify the response of osteosarcoma to doxorubicin in mouse - Primary Screen
Assay data:788 Active, 16789 Tested
SummaryPubMed Citation
Induction of mouse KCNQ2 expressed in HEK293 cells at -40 mV holding potential by whole-cell patch clamp assay
Assay data:7 Active, 1 Activity ≤ 1 nM, 5 Activity ≤ 1 µM, 9 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Induction of mouse KCNQ2 expressed in HEK293 cells at -40 mV holding potential by whole-cell patch clamp assay relative to (+/-)-N-(1-(benzo[d][1,3]dioxol-5-yl)ethyl)-3-(2-chlorophenyl)acrylamide
Assay data:7 Tested
SummaryPubMed CitationRelated BioAssays by Target
Induction of mouse KCNQ2 expressed in HEK293 cells at -40 mV holding potential by whole-cell patch clamp assay relative to retigabine
Assay data:1 Tested
Relative efficacy as ratio of maximal current amplitudes for compound and reference
Assay data:10 Tested
Effect on outward potassium currents in whole-cell patch clamp assay of HEK 293 cells expressing cloned mouse KCNQ2 channel at -40 mV
Assay data:10 Active, 6 Activity ≤ 1 µM, 10 Tested
Induced current in Xenopus laevis oocytes expressing cloned mKCNQ2 channels
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Threshold for augmenting KCNQ2 current in HEK 293 stable cell line expressing mKCNQ2 channel
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Whole-cell patch-clamp on recombinant mouse KCNQ2 channels expressed in HEK 293 cells at -40 mV
Assay data:6 Active, 3 Activity ≤ 1 µM, 6 Tested
Efficacy for mKCNQ2 expressed in HEK293 cells relative to reference compound
Assay data:6 Tested
Increased outward current at -40 mV mediated by mouse KCNQ2 channel expressed in Xenopus laevis oocytes at 5 uM; Insoluble
Increased outward current at -40 mV mediated by mouse KCNQ2 channel expressed in Xenopus laevis oocytes at 20 uM; Insoluble
Increased outward current at -40 mV mediated by mouse KCNQ2 channel expressed in Xenopus laevis oocytes at 20 uM
Assay data:11 Tested
Increased outward current at -40 mV mediated by mouse KCNQ2 channel expressed in Xenopus laevis oocytes at 1 uM
Assay data:3 Tested
Increased outward current at -40 mV mediated by mouse KCNQ2 channel expressed in Xenopus laevis oocytes at 100 nM
Increased outward current at -40 mV mediated by mouse KCNQ2 channel expressed in Xenopus laevis oocytes
Ability to open cloned mKCNQ2 channel expressed in Xenopus laevis oocytes at 10 uM expressed as percent of compound-free control current at -40 mV
Assay data:26 Tested
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