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Measurement of Inhibitory Activity on AT1 Receptor (AT1R)/AT2 Receptor (AT2R) from US Patent US11905274: "Receptor inhibitors, pharmaceutical compositions comprising the same and use thereof"
Assay data:72 Active, 71 Activity ≤ 1 µM, 72 Tested
SummaryRelated BioAssays by Target
Angiotensin AT1 Eurofins Panlabs panel
Assay data:1 Tested
Binding affinity towards human AGTR1 in an in vitro assay with cellular components measured by scintillation proximity assay
Assay data:7 Active, 2 Activity ≤ 1 nM, 7 Activity ≤ 1 µM, 7 Tested
Assay data:3 Active, 1 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 20 Tested
Assay data:26 Active, 5 Activity ≤ 1 nM, 11 Activity ≤ 1 µM, 1184 Tested
Displacement of [125I]-Angiotensin II from Angiotensin II type-1 receptor in VSMC cells (unknown origin) assessed as inhibition constant by competition radioligand binding assay
Assay data:13 Active, 13 Activity ≤ 1 µM, 13 Tested
Displacement of [125I]-Angiotensin II from Angiotensin II type-1 receptor in VSMC cells (unknown origin) by competition radioligand binding assay
GPCR beta-arrestin recruitment assay with target: AGTR1 Assay Type: PRESTO-Tango Concentration: 0.0000004
Assay data:211 Tested
GPCR beta-arrestin recruitment assay with target: AGTR1 Assay Type: PRESTO-Tango Concentration: 0.000002
GPCR beta-arrestin recruitment assay with target: AGTR1 Assay Type: PRESTO-Tango Concentration: 0.00001
Assay data:437 Tested
Displacement of [125-I]-[Sar1, Ile8]-angiotensin II from AT1R (unknown origin) by radioligand binding assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Displacement of [125-I]-[Sar1Ile8]-angiotensin II from human AT1R expressed in HEK293 cell membrane assessed as inhibition constant by radioligand binding assay
Assay data:8 Active, 12 Activity ≤ 1 µM, 21 Tested
Inhibition of human AT1R expressed in HEK293 cells by non-linear regression analysis
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Displacement of 125I-[Sar1,Ile8]ANGII form recombinant human full length AT1 receptor expressed in HEK293 cells incubated for 120 mins by scintillation counting method
Assay data:5 Active, 25 Activity ≤ 1 µM, 27 Tested
Displacement of 125I-[Sar1,Ile8]ANGII form AT1 receptor (unknown origin)
Inhibition of human AT1R expressed in CHO cells at 50 uM by Topcount beta counter analysis relative to control
SummaryPubMed CitationRelated BioAssays by Target
Angiotensin AT1 Eurofins-Panlabs radioligand binding assay
Displacement of [125I]-AT-II from human recombinant AT1 receptor at 10 uM after 120 mins by scintillation counting analysis relative to control
Displacement of [125-I]-[Sar1, AngII from AT1R (unknown origin) expressed in Escherichia coli BL 21 (DE3) incubated for 2 hrs by radioimmunoassay
Assay data:3 Active, 3 Activity ≤ 1 µM, 5 Tested
Binding affinity to AT1R (unknown origin) expressed in Escherichia coli strain BL 21 (DE3) incubated for 20 mins by SDS PAGE analysis
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
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