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Displacement of [3H]-PDBu from PKCdelta C1B domain in CD-1 mouse brain cytosol
Assay data:2 Active, 2 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of [3H]PDBu binding to PKCdelta C1B domain in CD-1 mouse brain cytosol incubated for 30 mins
Assay data:2 Active, 1 Activity ≤ 1 µM, 3 Tested
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen NFkB readout
Assay data:762 Active, 16821 Tested
SummaryRelated BioAssays by Same Project
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen TNF readout
Assay data:1106 Active, 16821 Tested
Displacement of [20-3H]PDBu from GST-tagged full-length mouse PKC-delta C1B domain expressed in Escherichia coli after 2 to 30 mins by polyethylene glycol precipitation assay in presence of phosphatidylserine
Assay data:15 Active, 4 Activity ≤ 1 nM, 12 Activity ≤ 1 µM, 15 Tested
A screen to identify the genes that modify the response of osteosarcoma to doxorubicin in mouse - Primary Screen
Assay data:788 Active, 16789 Tested
SummaryPubMed Citation
Effect on membrane translocation of PKCdelta-GFP Q257E mutant in CHOK1 cells at 20 uM within 10 mins
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Effect on membrane translocation of PKCdelta-GFP Q257E mutant in CHOK1 cells within 1 min in presence of PMA
Effect on membrane translocation of PKCdelta-GFP Q257E mutant in CHOK1 cells at 20 uM after 1 hr
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Effect on membrane translocation of wildype full length PKCdelta-GFP in CHOK1 cells at 20 uM within 5 mins
Ratio of Ki for mouse PKC delta C1a Q27E mutant to mouse wild-type PKCdelta C1a
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Binding affinity to mouse wild-type PKCdelta C1a expressed in Escherichia coli
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
Binding affinity to mouse PKC delta C1a Q27E mutant expressed in Escherichia coli
Assay data:3 Active, 2 Activity ≤ 1 µM, 3 Tested
Ratio of Ki for mouse wild type C1b domain of PKCdelta to Ki for mouse PKCdelta C1b Q27E mutant
Assay data:1 Active, 1 Activity ≤ 1 µM, 7 Tested
Displacement of [3H]PDBu from mouse PKCdelta C1b Q27E mutant expressed in Escherichia coli
Assay data:7 Active, 4 Activity ≤ 1 µM, 7 Tested
Displacement of [3H]PDBu from mouse wild type C1b domain of PKCdelta expressed in Escherichia coli
Assay data:7 Active, 4 Activity ≤ 1 nM, 7 Activity ≤ 1 µM, 7 Tested
Ratio of binding to PKC delta C1b domain wild type and mutant (Tyr8 to Gly)
Ratio of binding to PKC delta C1b domain wild type and mutant (Trp22 to Gly)
Ratio of binding to PKC delta C1b domain wild type and mutant (Thr12 to Gly)
Ratio of binding to PKC delta C1b domain wild type and mutant (Pro11 to Gly)
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