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Antagonist activity at LPA1 receptor (unknown origin) expressed in cells assessed as blockade of LPA-induced calcium mobilization at 10 uM measured after 120 secs by Fluo-4 NW dye based assay
Assay data:20 Tested
SummaryPubMed CitationRelated BioAssays by Target
Antagonist activity at LPA1 receptor (unknown origin) expressed in cells assessed as maximal blockade of LPA-induced calcium mobilization at 10 uM measured after 120 secs by Fluo-4 NW dye based assay relative to control
Assay data:1 Tested
Antagonist activity at LPA1 receptor (unknown origin) expressed in cells assessed as blockade of LPA-induced calcium mobilization measured after 120 secs by Fluo-4 NW dye based assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Antagonist activity at LPA1 receptor in human lung fibroblast cells assessed as inhibition of LPA stimulated calcium flux incubated for 20 mins followed by LPA stimulation and measured for 90 seconds
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
Antagonist activity at human LPA1 receptor expressed in CHO cells assessed as inhibition of LPA stimulated calcium flux incubated for 20 mins followed by LPS stimulation and measured for 90 seconds
Assay data:30 Active, 1 Activity ≤ 1 nM, 30 Activity ≤ 1 µM, 36 Tested
LPAR1 Membrane Binding Assay from US Patent US11365185: "Lysophosphatidic acid receptor 1 (LPAR1) inhibitor compounds"
Assay data:18 Active, 18 Activity ≤ 1 µM, 18 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
LPAR1 Calcium Flux Assays from US Patent US11365185: "Lysophosphatidic acid receptor 1 (LPAR1) inhibitor compounds"
Assay data:27 Active, 27 Activity ≤ 1 µM, 27 Tested
Receptor Assay from US Patent US9464060: "Compounds"
Assay data:53 Active, 3 Activity ≤ 1 nM, 53 Activity ≤ 1 µM, 53 Tested
Calcium Flux Assay Using Fluorometric Imaging Plate Reader (FLIPR) Assay from US Patent US9321738: "N-alkyltriazole compounds as LPAR antagonists"
Assay data:11 Active, 9 Activity ≤ 1 µM, 14 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
In Vitro LPA1 Receptor Assay from US Patent US10100018: "Amide derivatives as lysophosphatidic acid receptor antagonists"
Assay data:83 Active, 5 Activity ≤ 1 nM, 80 Activity ≤ 1 µM, 83 Tested
PRESTO-Tango GPCRome screening (LPAR1)
SummaryRelated BioAssays by Target
Inhibition of LPA1 (unknown origin)
Inhibition of LPA in human plasma after 18 hrs by LC-MS/MS analysis
Inhibition of LPAR1 (unknown origin)
Agonist activity at human Flag-tagged LPA1 receptor expressed in rat B103 cells co-expressing EGFP assessed as induction of LPA1 receptor internalization at 1 uM after 15 mins by phalloidin/DAPI staining based confocal fluorescence microscopy
Assay data:2 Active, 2 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Agonist activity at human Flag-tagged LPA1 expressed in rat B103 cells co-expressing EGFP assessed as induction of cell migration at 1 uM after 5 hrs by crystal violet staining based microscopic transwell assay
Agonist activity at human Flag-tagged LPA1 expressed in rat B103 cells co-expressing EGFP assessed as induction of neurite retraction by measuring rounded cells at 1 uM after 15 mins by phalloidin/DAPI staining based fluorescence microscopy
Reversible covalent binding affinity to LPA1 (unknown origin) stably expressed in rat RH7777 cells assessed as increase in intracellular calcium level preincubated followed by compound washout and subsequent compound dosing and measured after 30 mins by Fluo-4 NW dye based fluorescence assay
Binding affinity to LPA1 receptor (unknown origin) by cell-based backscattering interferometry
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Agonist activity at LPA1 receptor (unknown origin) stably expressed in rat RH7777 cells assessed as increase in intracellular calcium level by Fluo-4 NW dye based fluorescence assay
Assay data:16 Active, 5 Activity ≤ 1 µM, 18 Tested
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