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Inhibition of ACAT in mouse 3T3-L1 cells assessed as reduction in adiponectin expression level at 10 uM dosed during day 2 to 6 and followed by drug replacement every 48 hrs by LC-MS/MS analysis based proteomic analysis
Assay data:1 Tested
SummaryRelated BioAssays by Target
Inhibition of ACAT in mouse 3T3-L1 cells assessed as reduction in hydroxy-steroid (17-beta) dehydrogenase 4 expression level at 10 uM dosed during day 2 to 6 and followed by drug replacement every 48 hrs by LC-MS/MS analysis based proteomic analysis
Inhibition of ACAT in mouse 3T3-L1 cells assessed as reduction in carnitine O-acetyltransferase expression level at 10 uM dosed during day 2 to 6 and followed by drug replacement every 48 hrs by LC-MS/MS analysis based proteomic analysis
Inhibition of ACAT in mouse 3T3-L1 cells assessed as reduction in acetyl-CoA acyltransferase 1 expression level at 10 uM dosed during day 2 to 6 and followed by drug replacement every 48 hrs by LC-MS/MS analysis based proteomic analysis
Inhibition of ACAT in mouse 3T3-L1 cells assessed as reduction in hydroxyacyl-CoA dehydrogenase expression level at 10 uM dosed during day 2 to 6 and followed by drug replacement every 48 hrs by LC-MS/MS analysis based proteomic analysis
Inhibition of ACAT in mouse 3T3-L1 cells assessed as reduction in enoyl CoA hydratase short chain 1 expression level at 10 uM dosed during day 2 to 6 and followed by drug replacement every 48 hrs by LC-MS/MS analysis based proteomic analysis
Inhibition of ACAT in mouse 3T3-L1 cells assessed as reduction in Acyl-CoA dehydrogenase expression level at 10 uM dosed during day 2 to 6 and followed by drug replacement every 48 hrs by LC-MS/MS analysis based proteomic analysis
Inhibition of ACAT in mouse 3T3-L1 cells assessed as reduction in FAS expression level at 10 uM dosed during day 2 to 6 and followed by drug replacement every 48 hrs by LC-MS/MS analysis based proteomic analysis
Inhibition of ACAT in mouse 3T3-L1 cells assessed as reduction in Acyl-CoA synthetase long-chain family member 1 expression level at 10 uM dosed during day 2 to 6 and followed by drug replacement every 48 hrs by LC-MS/MS analysis based proteomic analysis
Inhibition of ACAT in mouse 3T3-L1 cells assessed as reduction in accumulation of fluorescence-labeled CE by 25-NBD cholesterol based assay
Assay data:1 Active, 1 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Inhibition of ACAT1 in mouse IC21 cells in absence of BSA
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of ACAT1 in mouse IC21 cells in presence of BSA
Inhibition of ACAT1 in mouse J774 cells assessed as reduction in esterified cholesterol accumulation after 18 hrs in presence of 25-hydroxycholesterol
Assay data:57 Active, 31 Activity ≤ 1 µM, 63 Tested
Inhibition of ACAT1 in mouse J774 cells
Inhibition of ACAT1 in mouse N9 cells assessed as effect on autophagosome formation by measuring LC3-2 levels in presence of HMG CoA reductase inhibitor lovastatin
Inhibition of ACAT1 in mouse N9 cells assessed as effect on lysosome biogenesis by measuring cellular acidic compartments in presence of HMG CoA reductase inhibitor lovastatin by Lyso tracker staining based flow cytometry
Inhibition of ACAT1 in mouse N9 cells assessed as effect on autophagosome formation by measuring LC3-2 levels in presence of squalene synthase inhibitor CP-340868
Inhibition of ACAT1 in mouse N9 cells assessed as effect on lysosome biogenesis by measuring cellular acidic compartments in presence of squalene synthase inhibitor CP-340868 by Lyso tracker staining based flow cytometry
Inhibition of ACAT1 in TFEB knock-down mouse N9 cells assessed as increase in lysosome biogenesis by measuring Lyso tracker fluorescence measured after 8 hrs by Lyso tracker staining based flow cytometry
Inhibition of ACAT1 in TFEB knock-down mouse N9 cells assessed as autophagosome formation by measuring LC3-2 levels
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