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Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen NFkB readout
Assay data:762 Active, 16821 Tested
SummaryRelated BioAssays by Same Project
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced NF-kappaB and TNF-alpha responses in mouse macrophages_Primary screen TNF readout
Assay data:1106 Active, 16821 Tested
A screen to identify the genes that modify the response of osteosarcoma to doxorubicin in mouse - Primary Screen
Assay data:788 Active, 16789 Tested
SummaryPubMed Citation
Inhibition topoisomerase 1 in mouse NIH/3T3 cells assessed as conversion of supercoiled pBR322 DNA to relaxed form
Assay data:4 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of topoisomerase 1 extracted from mouse EAC cells assessed as inhibition of Escherichia coli pBR322 relaxation
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of DNA topoisomerase 1 in mouse P388/S cells assessed as formation of topoisomerase 1-DNA complex by proteinase K/SDS method
Assay data:26 Active, 20 Activity ≤ 1 µM, 30 Tested
Compound was tested for the inhibition topoisomerase I
Average concentration to cause 50% inhibition of topo 1 using the cleavable complex assay; ND indicates not determined
Assay data:2 Tested
Average concentration to cause 50% inhibition of topo 1 using the cleavable complex assay
Assay data:2 Active, 10 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
In vitro inhibitory activity against topoisomerase I (Topo I) by using relaxation assay
Assay data:5 Tested
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