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Antagonist activity against human P2X2R stably transfected in human 1321N1 cells assessed as ATP Emax at 0.4 uM incubated for 30 mins by Fura-2 AM staining based calcium influx assay relative to control
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Antagonist activity against human P2X2R stably transfected in human 1321N1 cells assessed as ATP Emax at 0.2 uM incubated for 30 mins by Fura-2 AM staining based calcium influx assay relative to control
Antagonist activity against human P2X2R stably transfected in human 1321N1 cells assessed as ATP Emax at 0.1 uM incubated for 30 mins by Fura-2 AM staining based calcium influx assay relative to control
Antagonist activity against human P2X2R stably transfected in human 1321N1 cells assessed as ATP EC50 at 0.4 uM incubated for 30 mins by Fura-2 AM staining based calcium influx assay
Antagonist activity against human P2X2R stably transfected in human 1321N1 cells assessed as ATP EC50 at 0.2 uM incubated for 30 mins by Fura-2 AM staining based calcium influx assay
Antagonist activity against human P2X2R stably transfected in human 1321N1 cells assessed as ATP EC50 at 0.1 uM incubated for 30 mins by Fura-2 AM staining based calcium influx assay
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Antagonist activity against human P2X2R stably transfected in human 1321N1 cells at 50 uM incubated for 30 mins by Fura-2 AM staining based calcium influx assay relative to control
Assay data:12 Tested
Antagonist activity against human P2X2R stably transfected in human 1321N1 cells incubated for 30 mins by Fura-2 AM staining based calcium influx assay
Assay data:6 Active, 2 Activity ≤ 1 µM, 9 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Negative allosteric modulation activity at human P2X2 receptor expressed in human 1321N1 cells assessed as reduction in intracellular Ca2+ influx incubated for 30 mins by Fura-2 AM based fluorescence assay relative to control
Assay data:2 Tested
Antagonist activity at human P2X2 receptor expressed in human 1321N1 cells assessed as reduction in intracellular Ca2+ influx incubated for 30 mins by Fura-2 AM based fluorescence assay relative to control
Assay data:11 Tested
Antagonist activity at human P2X2 receptor expressed in human 1321N1 cells assessed as reduction in intracellular Ca2+ influx incubated for 30 mins by Fura-2 AM based fluorescence assay
Assay data:8 Active, 2 Activity ≤ 1 µM, 10 Tested
Antagonist activity at human P2X2R/P2X3R expressing CHO cells assessed as reduction in intracellular Ca2+ influx pretreated with Fluo-4 for 1 hr followed by compound addition and further incubated for 30 mins in presence of ATP by multimode plate reader analysis
Assay data:3 Tested
Antagonist activity at human P2X2R expressing CHO cells assessed as reduction in intracellular Ca2+ influx pretreated with Fluo-4 for 1 hr followed by compound addition and further incubated for 30 mins in presence of ATP by multimode plate reader analysis
Assay data:1 Active, 3 Tested
Agonist activity at human P2X2R/P2X3R expressing CHO cells assessed as reduction in intracellular Ca2+ influx pretreated with Fluo-4 for 1 hr followed by compound addition and further incubated for 30 mins in presence of ATP by multimode plate reader analysis
Assay data:10 Active, 7 Activity ≤ 1 µM, 16 Tested
Agonist activity at human P2X2R expressing CHO cells assessed as reduction in intracellular Ca2+ influx pretreated with Fluo-4 for 1 hr followed by compound addition and further incubated for 30 mins in presence of ATP by multimode plate reader analysis
Assay data:5 Active, 3 Activity ≤ 1 µM, 16 Tested
Antagonist activity at human P2X2R/P2X3R by cell based assay
Assay data:3 Active, 3 Tested
Antagonist activity at human P2X2/3R transfected in CHO-K1 cells at 30 uM preincubated for 30 mins followed by alpha,beta-meATP addition by fluorescence based assay relative to control
Assay data:20 Tested
Antagonist activity at human P2X2/3R transfected in CHO-K1 cells preincubated for 30 mins followed by alpha,beta-meATP addition by fluorescence based assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 3 Tested
Antagonist activity at human P2X2R expressed in HEK293 cells assessed as reduction in intracellular Ca2+ influx at 10 uM pretreated with Fluo-4 for 1 hr followed by compound addition and further incubated for 30 mins in presence of ATP by multimode plate reader analysis relative to control
Assay data:4 Tested
Antagonist activity at P2X2 receptor (unknown origin)
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