BioAssay by Target (List) for Gene (Select 24521) - PubChem BioAssay - NCBI

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Items: 19

Select item 19301581.

Inhibition of rat ROMK

Source:: ChEMBL

Protein Target:: ATP-sensitive inward rectifier potassium channel 1

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1930158

Summary Related BioAssays by Target

Select item 18172982.

Inhibition of rat Kir1.1 expressed in HEK293 cells by electrophysiology assay

Source:: ChEMBL

Protein Target:: ATP-sensitive inward rectifier potassium channel 1

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1817298

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 18047563.

Inhibitory Activity Assay from US Patent US10759788: "Pharmaceutical uses of pyridine carboxamide derivatives"

Source:: BindingDB

Protein Targets:: ATP-sensitive inward rectifier potassium channel 1; ...
Total:: 2

Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested

AID:: 1804756

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Depositor Related BioAssays by Target

Select item 18037294.

Biological Assay from US Patent US10364234: "Pyridinecarboxamide derivatives, preparation method thereof and pharmaceutical uses thereof"

Source:: BindingDB

Protein Targets:: ATP-sensitive inward rectifier potassium channel 1; ...
Total:: 2

Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested

AID:: 1803729

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Depositor Related BioAssays by Target

Select item 18013545.

Thallium Flux Assay from US Patent US9062070: "Inhibitors of the renal outer medullary potassium channel"

Source:: BindingDB

Protein Targets:: ATP-sensitive inward rectifier potassium channel 1; ...
Total:: 1

Assay data:89 Active, 89 Activity ≤ 1 µM, 89 Tested

AID:: 1801354

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Depositor Related BioAssays by Target

Select item 18013536.

Electrophysiology Assay from US Patent US9062070: "Inhibitors of the renal outer medullary potassium channel"

Source:: BindingDB

Protein Targets:: ATP-sensitive inward rectifier potassium channel 1; ...
Total:: 1

Assay data:87 Active, 87 Activity ≤ 1 µM, 87 Tested

AID:: 1801353

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Depositor Related BioAssays by Target

Select item 18013257.

Electrophysiology Assay from US Patent US9056859: "Inhibitors of the renal outer medullary potassium channel"

Source:: BindingDB

Protein Targets:: ATP-sensitive inward rectifier potassium channel 1; ...
Total:: 1

Assay data:11 Active, 11 Activity ≤ 1 µM, 11 Tested

AID:: 1801325

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 18011968.

Electrophysiology Assay from US Patent US9018211: "Inhibitors of the renal outer medullary potassium channel"

Source:: BindingDB

Protein Targets:: ATP-sensitive inward rectifier potassium channel 1; ...
Total:: 1

Assay data:9 Active, 9 Activity ≤ 1 µM, 9 Tested

AID:: 1801196

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 15254599.

Inhibition of rat ROMK1 expressed in HEK293 cells by Tl+ flux assay

Source:: ChEMBL

Protein Target:: ATP-sensitive inward rectifier potassium channel 1

Assay data:8 Active, 7 Activity ≤ 1 µM, 8 Tested

AID:: 1525459

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 147486510.

Inhibition of rat ROMK expressed in HEK293 cells after 30 mins by FLIPR based thallium flux assay

Source:: ChEMBL

Protein Target:: ATP-sensitive inward rectifier potassium channel 1

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1474865

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 143700511.

Inhibition of rat ROMK expressed in HEK293 cells after 30 mins by thallium flux assay

Source:: ChEMBL

Protein Target:: ATP-sensitive inward rectifier potassium channel 1

Assay data:5 Active, 5 Activity ≤ 1 µM, 5 Tested

AID:: 1437005

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 135036912.

Inhibition of rat ROMK1 expressed in HEK293 cells after 20 mins by Thallos-AM dye based fluorescence assay

Source:: ChEMBL

Protein Target:: ATP-sensitive inward rectifier potassium channel 1

Assay data:1 Active, 1 Activity ≤ 1 µM, 4 Tested

AID:: 1350369

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 135036613.

Inhibition of rat ROMK2 expressed in HEK293 cells at -75 mV holding potential by whole cell patch clamp method

Source:: ChEMBL

Protein Target:: ATP-sensitive inward rectifier potassium channel 1

Assay data:2 Tested

AID:: 1350366

Summary PubMed Citation Related BioAssays by Target

Select item 134700714.

Rat Kir1.1 (Inwardly rectifying potassium channels)

Source:: IUPHAR/BPS Guide to PHARMACOLOGY

Protein Target:: ATP-sensitive inward rectifier potassium channel 1

Assay data:8 Active, 8 Tested

AID:: 1347007

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 129412715.

Inhibition of rat ROMK assessed as thallium flux after 30 mins in presence of ouabain by cell based FLIPR assay

Source:: ChEMBL

Protein Target:: ATP-sensitive inward rectifier potassium channel 1

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1294127

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 129410516.

Inhibition of rat ROMK expressed in HEK293 cells after 30 mins by [86Rb+] flux functional assay

Source:: ChEMBL

Protein Target:: ATP-sensitive inward rectifier potassium channel 1

Assay data:24 Active, 20 Activity ≤ 1 µM, 27 Tested

AID:: 1294105

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 124411317.

Inhibition of rat ROMK by thallium flux assay

Source:: ChEMBL

Protein Target:: ATP-sensitive inward rectifier potassium channel 1

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1244113

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 78007818.

Inhibition of rat ROMK channel-mediated 86Rb+ flux

Source:: ChEMBL

Protein Target:: ATP-sensitive inward rectifier potassium channel 1

Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested

AID:: 780078

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 68914919.

Inhibition of rat ROMK channel expressed in HEk293 cells assessed as inhibition of thallium efflux by fluorescence assay

Source:: ChEMBL

Protein Target:: ATP-sensitive inward rectifier potassium channel 1

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 689149

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

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Target

Proteins (1)
BioAssays with protein sequences specified as targets

BioActivity

Active Compounds (17)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 µM (16)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Confirmatory (17)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations

Depositor Category

Literature Extraction (19)
BioAssays extracted from the literature

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