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Displacement of [125I]-aminopotentidine from rat H2R expressed in human COS7 cells incubated for 90 mins gamma counting method
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Rat H2 receptor (Histamine receptors)
Assay data:8 Active, 8 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Antagonist at histamine H2 receptor in rat uterus assessed as inhibition of histamine-induced response
Assay data:11 Active, 2 Activity ≤ 1 µM, 12 Tested
Antagonist activity at histamine H2 receptor in Charles River rat assessed as inhibition of histamine-mediated electrically stimulated uterine contraction at 20 ug/mL relative to histamine-treated placebo
Assay data:12 Tested
SummaryPubMed CitationRelated BioAssays by Target
Antagonist activity at histamine H2 receptor in Charles River rat assessed as inhibition of histamine-mediated electrically stimulated uterine contraction
Assay data:22 Tested
Inhibition of rat histamine H2 receptor at 10 uM
Assay data:1 Tested
Inhibition of rat histamine H2 receptor at 1 uM
Assay data:2 Tested
Inhibition of H2 histamine receptor binding at a concentration of 10 uM; Showed negligible activities
Ability to displace [3H]tiotidine from histamine-H2 receptor at concentration of 10e-7 M
Ability to displace [3H]tiotidine from histamine-H2 receptor at concentration of 10e-5 M
Competitive binding at Histamine H2 receptor at 10 uM; NA means compound failed to compete
Inhibitory activity against binding of [125I]-(Nle11)-HG-13 to Histamine H2 receptor in vitro; ND = Not determined
Inhibitory activity against binding of [125I](Nle11)-HG-13 to Histamine H2 receptor in vitro
Assay data:23 Tested
Affinity to the Histamine H2 receptor was determined expressed in CHO cell using [125I]iodoaminopotentidine as radioligand
Assay data:1 Active, 3 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Antagonistic activity by inhibition histamine H2 receptor from rats.
Assay data:17 Active, 14 Activity ≤ 1 µM, 17 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Antagonistic activity for inhibition of histamine H2 receptor from anesthetized rats
Assay data:23 Active, 17 Activity ≤ 1 µM, 29 Tested
In vivo antagonist activity against histamine H2-receptor in lumen-perfused stomach of atropinized (1 mg/kg) anesthetized rat gastric secretion at 512 ug/kg; -ve
In vivo antagonist activity against histamine H2-receptor in lumen-perfused stomach of atropinized (1 mg/kg) anesthetized rat gastric secretion at 256 ug/kg; -ve
In vivo antagonist activity against histamine H2-receptor in lumen-perfused stomach of atropinized (1 mg/kg) anesthetized rat gastric secretion at 187 ug/kg; weak inhibition
Assay data:1 Active, 1 Tested
In vivo antagonist activity against histamine H2-receptor in lumen-perfused stomach of atropinized (1 mg/kg) anesthetized rat gastric secretion at 128 ug/kg; -ve
Assay data:4 Tested
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