BioAssay by Target (List) for Gene (Select 2560) - PubChem BioAssay - NCBI

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Select item 19632461.

Cross screening panel

Source:: ChEMBL

Protein Targets:: Gamma-aminobutyric acid receptor subunit alpha-1; ...
Total:: 16

Assay data:1 Tested

AID:: 1963246

Summary Related BioAssays by Target

Select item 19632452.

Cross screening panel

Source:: ChEMBL

Protein Targets:: Gamma-aminobutyric acid receptor subunit alpha-5; ...
Total:: 16

Assay data:1 Tested

AID:: 1963245

Summary Related BioAssays by Target

Select item 19632443.

Cross screening panel

Source:: ChEMBL

Protein Targets:: Gamma-aminobutyric acid receptor subunit alpha-4; ...
Total:: 16

Assay data:1 Tested

AID:: 1963244

Summary Related BioAssays by Target

Select item 19631984.

Cross screening panel

Source:: ChEMBL

Protein Targets:: Gamma-aminobutyric acid receptor subunit alpha-3; ...
Total:: 16

Assay data:1 Tested

AID:: 1963198

Summary Related BioAssays by Target

Select item 19631975.

Cross screening panel

Source:: ChEMBL

Protein Targets:: Gamma-aminobutyric acid receptor subunit alpha-5; ...
Total:: 16

Assay data:1 Tested

AID:: 1963197

Summary Related BioAssays by Target

Select item 19631966.

Cross screening panel

Source:: ChEMBL

Protein Targets:: Gamma-aminobutyric acid receptor subunit alpha-2; ...
Total:: 16

Assay data:1 Tested

AID:: 1963196

Summary Related BioAssays by Target

Select item 19612487.

Inhibition of GABAA receptor (unknown origin) upto 10000 nM

Source:: ChEMBL

Protein Targets:: Gamma-aminobutyric acid receptor subunit alpha-1; ...
Total:: 16

Assay data:1 Tested

AID:: 1961248

Summary Related BioAssays by Target

Select item 19597018.

Positive allosteric modulation of human GABAA alpha2beta1gamma2 receptor expressed in Xenopus laevis oocytes by two-microelectrode voltage-clamp assay

Source:: ChEMBL

Protein Targets:: Gamma-aminobutyric acid receptor subunit alpha-2; ...
Total:: 3

Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested

AID:: 1959701

Summary Related BioAssays by Target

Select item 19596849.

Potentiation of NAS mediated GABA (unknown origin) tonic effect assessed as fold potentiation

Source:: ChEMBL

Protein Targets:: Gamma-aminobutyric acid receptor subunit alpha-1; ...
Total:: 16

Assay data:6 Tested

AID:: 1959684

Summary Related BioAssays by Target

Select item 194133710.

Positive allosteric modulator activity at human GABAA receptor measured by [35S]TBPS based functional assay

Source:: ChEMBL

Protein Targets:: Gamma-aminobutyric acid receptor subunit alpha-1; ...
Total:: 16

Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested

AID:: 1941337

Summary Related BioAssays by Target

Select item 194070211.

Inhibition of GABAA receptor (unknown origin) at 50 uM by radioligand receptor binding assay relative to control

Source:: ChEMBL

Protein Targets:: Gamma-aminobutyric acid receptor subunit alpha-1; ...
Total:: 16

Assay data:23 Tested

AID:: 1940702

Summary Related BioAssays by Target

Select item 193409412.

Inhibition of GABA-A receptor (unknown origin)

Source:: ChEMBL

Protein Targets:: Gamma-aminobutyric acid receptor subunit alpha-1; ...
Total:: 16

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1934094

Summary Related BioAssays by Target

Select item 193230513.

Inhibition of GABAA receptor (unknown origin)

Source:: ChEMBL

Protein Targets:: Gamma-aminobutyric acid receptor subunit alpha-1; ...
Total:: 16

Assay data:9 Active, 4 Activity ≤ 1 nM, 9 Activity ≤ 1 µM, 10 Tested

AID:: 1932305

Summary Related BioAssays by Target

Select item 193229014.

Displacement of [3H]flunitrazepam from GABAA (unknown origin ) receptor by radioligand binding assay

Source:: ChEMBL

Protein Targets:: Gamma-aminobutyric acid receptor subunit alpha-1; ...
Total:: 16

Assay data:21 Active, 12 Activity ≤ 1 nM, 19 Activity ≤ 1 µM, 25 Tested

AID:: 1932290

Summary Related BioAssays by Target

Select item 192575415.

Inhibition of GABAA receptor (unknown origin) at 10 uM

Source:: ChEMBL

Protein Targets:: Gamma-aminobutyric acid receptor subunit alpha-1; ...
Total:: 16

Assay data:1 Tested

AID:: 1925754

Summary Related BioAssays by Target

Select item 192073516.

Inhibition of GABAA receptors (unknown origin)

Source:: ChEMBL

Protein Targets:: Gamma-aminobutyric acid receptor subunit alpha-5; ...
Total:: 16

Assay data:1 Tested

AID:: 1920735

Summary Related BioAssays by Target

Select item 191240817.

Binding affinity to GABAA receptor (unknown origin) at 10000 nM by radioligand displacement assay relative to control

Source:: ChEMBL

Protein Targets:: Gamma-aminobutyric acid receptor subunit alpha-1; ...
Total:: 16

Assay data:1 Tested

AID:: 1912408

Summary PubMed Citation Related BioAssays by Target

Select item 188509818.

Binding affinity to GABA A receptor (unknown origin)

Source:: ChEMBL

Protein Targets:: Gamma-aminobutyric acid receptor subunit alpha-1; ...
Total:: 16

Assay data:2 Active, 2 Tested

AID:: 1885098

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 188020319.

Inhibition of GABA-A receptor (unknown origin)

Source:: ChEMBL

Protein Targets:: Gamma-aminobutyric acid receptor subunit alpha-1; ...
Total:: 16

Assay data:4 Tested

AID:: 1880203

Summary PubMed Citation Related BioAssays by Target

Select item 187764020.

Inhibition of GABAA receptor (unknown origin) at 50 uM by radioligand receptor binding assay relative to control

Source:: ChEMBL

Protein Targets:: Gamma-aminobutyric acid receptor subunit alpha-1; ...
Total:: 16

Assay data:20 Tested

AID:: 1877640

Summary PubMed Citation Related BioAssays by Target

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Target

Proteins (1)
BioAssays with protein sequences specified as targets
RNAi Target, Active (6)
BioAssays with gene sequences specified as RNAi targets and the activity is active

BioActivity

Active Compounds (83)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (8)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (60)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Summary (1)
BioAssays summarizing information from multiple assays for validated chemical probes or small molecule leads
Confirmatory (116)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
Primary Screening (9)
Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose
Chemical Screens (237)
BioAssays reporting BioActivity of chemical reagents
RNAi Screens (13)
BioAssays reporting BioActivity of RNAi reagents

Assay Project (1)
BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

Depositor Category

Literature Extraction (209)
BioAssays extracted from the literature
NIH MLP (1)
BioAssays deposited by the NIH Molecular Libraries Program
Other (40)
BioAssays deposited by other experimentalists

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