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Test for Evaluating Rat MC4 Receptor Activation, Using Cells Expressing Rat MC4 Receptor from US Patent US10301286: "Piperazine derivative"
Assay data:8 Active, 8 Activity ≤ 1 µM, 8 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Rat MC4 receptor (Melanocortin receptors)
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Agonist activity at rat MC4 receptor
Assay data:3 Active, 3 Tested
Agonist activity at rat melanocortin 4 receptor expressed in CHO cells assessed as cAMP release at 10 uM relative to alpha-MSH
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Agonist activity at rat melanocortin 4 receptor expressed in CHO cells assessed as cAMP release
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Agonist activity at rat MC4R expressed in CHO cells assessed as stimulation of intracellular cAMP accumulation at 10 uM relative to alpha-MSH
Agonist activity at rat MC4R expressed in CHO cells assessed as stimulation of intracellular cAMP accumulation
Binding affinity at rat MC4R
Agonist activity at rat MC4R expressed in CHO cells assessed as cAMP release at 10 uM relative to alpha-MSH
Assay data:5 Tested
Agonist activity at rat MC4R expressed in CHO cells assessed as cAMP release
Assay data:3 Active, 2 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 3 Tested
Binding affinity to rat MC4R
Assay data:4 Active, 2 Activity ≤ 1 nM, 4 Activity ≤ 1 µM, 4 Tested
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
Binding affinity to rat MC4 receptor
Concentration of compound at 50% maximum cAMP accumulation at rat melanocortin-4 receptor
Concentration of compound at 50% maximum cAMP accumulation in rat melanocortin receptor (rMC4R)
Inhibition concentration (binding affinity) against rat melanocortin receptor 4 by displacement of [125I]NDP-alpha-MSH from the human receptors expressed in CHO cells
Binding affinity for rat melanocortin-4 receptor
Assay data:2 Active, 2 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested
Percentage of cAMP accumulation at 10 uM relative to alpha-MSH at rat Melanocortin-4 receptor
Evaluated for binding affinity against rat Melanocortin-4 receptor (rMC4R) by displacing [125I]NDP-alpha-MSH radioligand expressed in CHO cells
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