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Inhibition of LPS-induced p38 phosphorylation in mouse BV-2 cells at 5 to 20 uM pretreated for 30 mins followed by LPS stimulation by Western blot analysis
Assay data:1 Tested
SummaryRelated BioAssays by Target
Inhibition of P38 phosphorylation in R848-stimulated mouse BMDC cells at 1 to 4 uM treated for 2 hrs followed by R848 stimulation for 12 hrs by western blot analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of p38 phosphorylation in LPS-induced mouse RAW264.7 cells at 3.125 to 12.5 uM measured after 24 hrs by Western blot analysis
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of LPS-induced p38 MAPK phosphorylation in mouse RAW264.7 cells pretreated with compound for 2 hrs followed by LPS-stimulation for 30 mins by Western blot analysis
Inhibition of LPS-induced p38 MAPK phosphorylation in mouse RAW264.7 cells at 0.2 to 5 uM pretreated with compound for 2 hrs followed by LPS-stimulation for 30 mins by Western blot analysis
Assay data:2 Tested
Inhibition of p38 MAPK activation in mouse RAW264.7 cells assessed as RANKL-induced JNK phosphorylation upto 8 uM pretreated with compounds for 24 hrs followed by RANKL stimulation for 10 to 20 mins by Western blot analysis
Inhibition of p38 MAPK activation in mouse RAW264.7 cells assessed as RANKL-induced ERK phosphorylation upto 8 uM pretreated with compounds for 24 hrs followed by RANKL stimulation for 10 to 20 mins by Western blot analysis
Fluorescence Quenching Assay from US Patent US9115122: "Non-ATP dependent inhibitors of extracellular signal-regulated kinase (ERK)"
Assay data:8 Active, 2 Activity ≤ 1 µM, 8 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Enzyme Inhibition Scintillation Proximity Assay from Article 10.1016/j.bmcl.2006.05.045: "p38 MAP kinase inhibitors. Part 3: SAR on 3,4-dihydropyrimido[4,5-d]pyrimidin-2-ones and 3,4-dihydropyrido[4,3-d]pyrimidin-2-ones."
Assay data:28 Active, 9 Activity ≤ 1 nM, 28 Activity ≤ 1 µM, 28 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Enzyme Inhibition Scintillation Proximity Assay from Article 10.1016/j.bmcl.2006.08.074: "p38 MAP kinase inhibitors. Part 6: 2-arylpyridazin-3-ones as templates for inhibitor design."
Assay data:18 Active, 16 Activity ≤ 1 µM, 18 Tested
Enzyme Inhibition Scintillation Proximity Assay from Article 10.1038/nsb949: "Structural basis for p38alpha MAP kinase quinazolinone and pyridol-pyrimidine inhibitor specificity."
Assay data:6 Active, 3 Activity ≤ 1 nM, 6 Activity ≤ 1 µM, 6 Tested
UV-Thermal Melt from Article 10.1021/jm030121k: "Structure-activity relationships of the p38alpha MAP kinase inhibitor 1-(5-tert-butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)naph- thalen-1-yl]urea (BIRB 796)."
Assay data:9 Active, 3 Activity ≤ 1 nM, 8 Activity ≤ 1 µM, 9 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Thermal Denaturation Assay from Article 10.1021/jm030121k: "Structure-activity relationships of the p38alpha MAP kinase inhibitor 1-(5-tert-butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)naph- thalen-1-yl]urea (BIRB 796)."
Assay data:18 Active, 8 Activity ≤ 1 nM, 18 Activity ≤ 1 µM, 18 Tested
Fluorescence Exchange Curve Assay from Article 10.1021/jm030120s: "Thermal denaturation: a method to rank slow binding, high-affinity P38alpha MAP kinase inhibitors."
Assay data:9 Active, 4 Activity ≤ 1 nM, 8 Activity ≤ 1 µM, 9 Tested
Inhibition of p38 MAPK phosphorylation in LPS-stimulated mouse BV-2 cells measured after 2 hrs by western blot analysis
Inhibition of p38 phosphorylation in LPS-stimulated mouse BV-2 cells at 15 to 60 uM pretreated with compound for 1 hr followed by LPS stimulation for 24 hrs by Western blot analysis
Inhibition of p38 MAPK phosphorylation in LPS-induced mouse RAW264.7 cells at 0.75 to 3 uM preincubated for 2 hrs followed by LPS stimulation and measured after 30 mins by immunoblotting assay
Inhibition of p38 phosphorylation in LPS stimulated mouse BV-2 cells at 1 to 10 uM preincubated with LPS for 1 hr followed by incubation with compound for 16 hrs by western blot analysis
Inhibition of RANKL-induced p38 phosphorylation in mouse RAW264.7 cells at 1 to 10 uM pretreated for 4 hrs prior to RANKL stimulation for 20 mins by western blot analysis
Inhibition of glutamate-induced p38 MAPK activation in mouse HT-22 cells assessed as reduction in phosphorylated p38 MAPK protein level at 1 to 10 uM in presence of glutamate by Western blot analysis
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