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Evaluation of Activity to Inhibit Generation of Reactive Oxygen Species and Spore Germination Through NOX Enzyme Inhibition from US Patent US20230286956: "1-ALKYL-5-ARYLIDENE-2-SELENOXOIMIDAZOLIDINE-4-ON AND DERIVATIVE THEREOF, PREPARATION METHOD THEREFOR, AND COMPOSITION COMPRISING SAME FOR PREVENTING, ALLEVIATING OR TREATING NEURODEGENERATIVE DISEASES"
Assay data:15 Active, 5 Activity ≤ 1 µM, 59 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition of human NOX1
Assay data:1 Active, 2 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Nox1 Assay from US Patent US10173988: "N2-(3,4-dimethylphenyl)-6-((4-(p-tolyl)piperazin-1-yl)methyl)-1,3,5-triazine-2,4-diamine"
Assay data:5 Tested
SummaryRelated BioAssays by DepositorRelated BioAssays by Target
ROS Production Measurement on hNOX1 Membranes from US Patent US10130619: "Amido thiadiazole derivatives as NADPH oxidase inhibitors"
Assay data:70 Active, 70 Activity ≤ 1 µM, 70 Tested
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Summary
Potency index, ratio of Ki for Ewha-89403 to Ki for test compound for inhibition of human NOX1 expressed in Drosophila DUOX knockdown model
Assay data:2 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of human NOX1 expressed in Drosophila DUOX knockdown model assessed as decrease in ROS production by lucigenin chemiluminescence assay
Assay data:11 Active, 1 Activity ≤ 1 µM, 19 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of human Nox1 expressed in COS7 cells co-transfected with human co-transfected with human NOXO1/NOXA1 assessed as inhibition of PMA-induced ROS production at 10 uM
SummaryCompounds, ActiveRelated BioAssays by Target
Inhibition of human Nox1 expressed in COS7 cells co-transfected with human NOXO1/NOXA1 assessed as inhibition of PMA-induced superoxide generation by L-012 chemiluminescence analysis
Assay data:18 Tested
SummaryRelated BioAssays by Target
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced TNF-alpha response in human macrophages_Primary screen TNF readout
Assay data:2853 Active, 18113 Tested
SummaryRelated BioAssays by Same Project
Inhibition of full length human NOX1 transfected in COS 22 cells assessed as inhibition of Phorbol 12-myristate 13-acetate-stimulated ROS generation by chemiluminescence assay
A screen to identify synthetic lethal interactions with E-cadherin in an MCF10A isogenic cell line
Assay data:2442 Active, 18052 Tested
SummaryPubMed Citation
A screen to identify genes that regulate lymphatic endothelial cell migration - Primary Screen
Assay data:1034 Active, 18120 Tested
SummaryRelated BioAssays by Depositor
Identification of proteins required for the processing of the EWS-FLI1 nascent transcript
Assay data:59220 Tested
InfectX: Pathogen infection siRNA screens
Assay data:115372 Tested
A whole genome RNAi screen highlights components of the ER/Golgi as a prominent source of resistance to immunotoxin-mediated cytotoxicity
Assay data:555 Active, 64752 Tested
RNAi screen for vorinostat resistance genes - Primary Screen
Assay data:450 Active, 18118 Tested
Druggable Genome siRNA Screen for Enhancers of Camptothecin in MDA-MB-231 Breast Cancer Cells
Assay data:167 Active, 26449 Tested
Genome-wide high-content siRNA screens for regulators of Parkin translocation in selective mitophagy (Ambion Library)
Assay data:9227 Active, 64752 Tested
Genome-wide high-content siRNA screens for regulators of Parkin translocation in selective mitophagy (Dharmacon Library)
Assay data:826 Active, 18119 Tested
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