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Binding affinity to recombinant human Fc-fused siglec-7 expressed in CHO cells measured over 180 secs
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Binding affinity to recombinant human Fc-fused siglec-7 after 1 hr by fluorescence based glycan microarray analysis
Assay data:6 Active, 6 Activity ≤ 1 µM, 6 Tested
Binding affinity to recombinant human Fc-fused siglec-7 by fluorescence based glycan microarray analysis
Assay data:4 Active, 9 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Summary
Binding affinity to human IgG1-fused Siglec-7-Fc
Assay data:3 Tested
SummaryPubMed CitationRelated BioAssays by Target
Ratio of 3'sialyllactose Kd to relative inhibitory potency of test compound for human IgG1-fused Siglec-7-Fc by ELISA
Assay data:2 Tested
Binding affinity to Siglec-7 in IL-2 activated human NK cells assessed as increase in NK cell-mediated 51Cr labeled human MEL1106 cell lysis by measuring 51Cr release preincubated for 15 mins followed by MEL1106 cell addition measured after 4 hrs by gamma-counting method
Assay data:1 Active, 1 Tested
Binding affinity to human IgG1-fused Siglec-7-Fc measured after 2.5 hrs by ELISA relative to 3'sialyllactose
Binding affinity to human IgG1-fused Siglec-7-Fc measured after 2.5 hrs by ELISA
Assay data:4 Tested
Binding affinity to human IgG1-fused Siglec-7-Fc assessed as inhibition of Siglec-7-Fc binding to RBC preincubated for 10 mins followed by RBC addition measured after 20 mins by FACS analysis
Assay data:2 Active, 6 Tested
Binding affinity to human IgG1-fused Siglec-7-Fc assessed as inhibition of Siglec-7-Fc binding to RBC preincubated for 10 mins followed by RBC addition measured after 20 mins by FACS analysis relative to sodium (4S,5R,6R)-5-acetamido-4-hydroxy-2-methoxy-6-((1R,2R)-1,2,3 trihydroxypropyl)tetrahydro-2H-pyran-2-carboxylate
Assay data:36 Tested
Potency index, ratio of IC50 for compound-1 to IC50 for test compound for binding affinity to human IgG1-fused human Siglec-7-FC (Gln19 to Gly357 residues) assessed as inhibition Siglec-7-Fc binding to to RBC pre-incubated for 10 mins before 20 mins incubation with RBCs by flow cytometry
Assay data:10 Tested
Binding affinity to human IgG1-fused human Siglec-7-FC (Gln19 to Gly357 residues) assessed as inhibition Siglec-7-Fc binding to to RBC pre-incubated for 10 mins before 20 mins incubation with RBCs by flow cytometry
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced TNF-alpha response in human macrophages_Primary screen TNF readout
Assay data:2853 Active, 18113 Tested
SummaryRelated BioAssays by Same Project
A screen to identify synthetic lethal interactions with E-cadherin in an MCF10A isogenic cell line
Assay data:2442 Active, 18052 Tested
SummaryPubMed Citation
A screen to identify genes that regulate lymphatic endothelial cell migration - Primary Screen
Assay data:1034 Active, 18120 Tested
SummaryRelated BioAssays by Depositor
Identification of proteins required for the processing of the EWS-FLI1 nascent transcript
Assay data:59220 Tested
InfectX: Pathogen infection siRNA screens
Assay data:115372 Tested
A whole genome RNAi screen highlights components of the ER/Golgi as a prominent source of resistance to immunotoxin-mediated cytotoxicity
Assay data:555 Active, 64752 Tested
RNAi screen for vorinostat resistance genes - Primary Screen
Assay data:450 Active, 18118 Tested
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