BioAssay by Target (List) for Gene (Select 27330) - PubChem BioAssay - NCBI

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Select item 19498171.

Inhibition of RSK4 (unknown origin)

Source:: ChEMBL

Protein Target:: Ribosomal protein S6 kinase alpha-6

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1949817

Summary Related BioAssays by Target

Select item 19154862.

Selectivity interaction (Kinase Profiler (Millipore)) EUB0000603a RPS6KA6

Source:: ChEMBL

Protein Target:: Ribosomal protein S6 kinase alpha-6

Assay data:1 Tested

AID:: 1915486

Summary Related BioAssays by Target

Select item 19154393.

Selectivity interaction (KinomeScan (DiscoverX, competition-binding assay)) EUB0000154b RPS6KA6

Source:: ChEMBL

Protein Target:: Ribosomal protein S6 kinase alpha-6

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1915439

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19153924.

Selectivity interaction (KinomeScan (DiscoverX)) EUB0000586a RPS6KA6

Source:: ChEMBL

Protein Target:: Ribosomal protein S6 kinase alpha-6

Assay data:1 Tested

AID:: 1915392

Summary Related BioAssays by Target

Select item 19142085.

Selectivity interaction (Kinase panel (ProQinase, FlashPlate?-based radiometric assay, 10 M ATP)) EUB0000006b RPS6KA6

Source:: ChEMBL

Protein Target:: Ribosomal protein S6 kinase alpha-6

Assay data:1 Tested

AID:: 1914208

Summary Related BioAssays by Target

Select item 19139386.

Selectivity interaction (KinomeScan (DiscoverX)) EUB0000702a RPS6KA6

Source:: ChEMBL

Protein Target:: Ribosomal protein S6 kinase alpha-6

Assay data:1 Tested

AID:: 1913938

Summary Related BioAssays by Target

Select item 19138977.

Selectivity interaction (Enzymatic assay) EUB0000305b RPS6KA6

Source:: ChEMBL

Protein Target:: Ribosomal protein S6 kinase alpha-6

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1913897

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19138558.

Selectivity interaction (NanoBRET assay (HEK293T cells)) EUB0000132b RPS6KA6

Source:: ChEMBL

Protein Target:: Ribosomal protein S6 kinase alpha-6

Assay data:1 Tested

AID:: 1913855

Summary Related BioAssays by Target

Select item 19138549.

Selectivity interaction (KinomeScan (DiscoverX)) EUB0000132b RPS6KA6

Source:: ChEMBL

Protein Target:: Ribosomal protein S6 kinase alpha-6

Assay data:1 Tested

AID:: 1913854

Summary Related BioAssays by Target

Select item 191344910.

Selectivity interaction (Kinase panel (Millipore)) EUB0000153b RPS6KA6

Source:: ChEMBL

Protein Target:: Ribosomal protein S6 kinase alpha-6

Assay data:1 Tested

AID:: 1913449

Summary Related BioAssays by Target

Select item 183579711.

RSK4(Kin.Dom.2-C-terminal) DiscoveRx kinase panel

Source:: ChEMBL

Protein Target:: Ribosomal protein S6 kinase alpha-6

Assay data:1 Tested

AID:: 1835797

Summary Related BioAssays by Target

Select item 183579612.

RSK4(Kin.Dom.1-N-terminal) DiscoveRx kinase panel

Source:: ChEMBL

Protein Target:: Ribosomal protein S6 kinase alpha-6

Assay data:1 Tested

AID:: 1835796

Summary Related BioAssays by Target

Select item 183514613.

Rsk4(h) Kinase panel

Source:: ChEMBL

Protein Target:: Ribosomal protein S6 kinase alpha-6

Assay data:1 Tested

AID:: 1835146

Summary Related BioAssays by Target

Select item 183431614.

Inhibition of RSK4 (unknown origin) at 1 uM

Source:: ChEMBL

Protein Target:: Ribosomal protein S6 kinase alpha-6

Assay data:1 Tested

AID:: 1834316

Summary PubMed Citation Related BioAssays by Target

Select item 182346715.

Inhibition of RSK4 (unknown origin) at 1 uM by kinome scan method

Source:: ChEMBL

Protein Target:: Ribosomal protein S6 kinase alpha-6

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1823467

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 180474316.

Kinase Assay from US Patent US10758530: "Carboxamide derivatives useful as rsk inhibitors"

Source:: BindingDB

Protein Targets:: Ribosomal protein S6 kinase alpha-1; ...
Total:: 4

Assay data:7 Active, 1 Activity ≤ 1 nM, 10 Activity ≤ 1 µM, 20 Tested

AID:: 1804743

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 179850017.

Kinase Inhibition Assay from Article 10.1042/BJ20061088: "BI-D1870 is a specific inhibitor of the p90 RSK (ribosomal S6 kinase) isoforms in vitro and in vivo."

Source:: BindingDB

Protein Targets:: Aurora kinase B; ...
Total:: 10

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1798500

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 179720418.

Kinase Assay from US Patent US9771366: "Substituted tetrahydropyrido[3′,2′:4,5]pyrrolo[1,2-a]pyrazine-2-carboxamides as RSK inhibitors"

Source:: BindingDB

Protein Targets:: Ribosomal protein S6 kinase alpha-1; ...
Total:: 4

Assay data:2 Active, 1 Activity ≤ 1 nM, 6 Activity ≤ 1 µM, 20 Tested

AID:: 1797204

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 179433219.

KinomeScan assay: inhibition of RSK4(Kin.Dom.2-C-terminal)

Source:: ChEMBL

Protein Target:: Ribosomal protein S6 kinase alpha-6

Assay data:1 Active, 108 Tested

AID:: 1794332

Summary Compounds, Active Related BioAssays by Target

Select item 179433120.

KinomeScan assay: inhibition of RSK4(Kin.Dom.1-N-terminal)

Source:: ChEMBL

Protein Target:: Ribosomal protein S6 kinase alpha-6

Assay data:2 Active, 108 Tested

AID:: 1794331

Summary Compounds, Active Related BioAssays by Target

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Target

Proteins (3)
BioAssays with protein sequences specified as targets
RNAi Target, Active (8)
BioAssays with gene sequences specified as RNAi targets and the activity is active

BioActivity

Active Compounds (39)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (6)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (32)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Summary (1)
BioAssays summarizing information from multiple assays for validated chemical probes or small molecule leads
Confirmatory (41)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
Primary Screening (40)
Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose
Chemical Screens (218)
BioAssays reporting BioActivity of chemical reagents
RNAi Screens (44)
BioAssays reporting BioActivity of RNAi reagents

Assay Project (1)
BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

Depositor Category

Literature Extraction (168)
BioAssays extracted from the literature
NIH MLP (2)
BioAssays deposited by the NIH Molecular Libraries Program
Other (91)
BioAssays deposited by other experimentalists

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