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Inhibition of recombinant human HTRA2 using H2-OPT as substrate assessed as increase in fluorescence at 1 uM and measured for 2 hrs by fluorescent plate reader analysis
Assay data:1 Tested
SummaryRelated BioAssays by Target
Inhibition of recombinant human HTRA2 using H2-OPT as substrate assessed as increase in fluorescence and measured for 2 hrs by fluorescent plate reader analysis
Assay data:5 Active, 10 Tested
Binding affinity to recombinant human HTRA2 assessed as increase in fluorescence using H2-OPT as substrate at 1 uM by SDS-PAGE based gel fluorescence scanning analysis
Assay data:6 Active, 9 Tested
Chromogenic Enzyme Activity Assays from US Patent US11149067: "Tailored cyclodepsipeptides as potent non-covalent serine protease inhibitors"
Assay data:31 Active, 19 Activity ≤ 1 µM, 33 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition of His-tagged Omi/HtrA2 (134 to 458 residues) (unknown origin) expressed in TB1 Escherichia coli at 10 to 50 uM pre-incubated for 15 mins before FITC-labeled dephosphorylated casein substrate addition and measured every 5 mins for 30 mins by fluorescence assay
Inhibition of His-tagged Omi/HtrA2 (134 to 458 residues) (unknown origin) expressed in TB1 Escherichia coli at 80 uM pre-incubated for 10 mins before un-labeled beta-casein substrate addition and measured after 30 mins by Coomassie blue staining based SDS-PAGE analysis
Inhibition of His-tagged Omi/HtrA2 (134 to 458 residues) (unknown origin) expressed in TB1 Escherichia coli at 10 to 100 uM pre-incubated for 10 mins before un-labeled beta-casein substrate addition and measured after 30 mins by Coomassie blue staining based SDS-PAGE analysis
Assay data:1 Active, 2 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Inhibition of MBP-fused Omi/HtrA2 (134 to 458 residues) (unknown origin) expressed in TB1 Escherichia coli at 10 uM pre-incubated for 15 mins before higher 2 times FITC-labeled dephosphorylated casein substrate addition and measured every 5 mins for 30 mins by fluorescence assay
Irreversible inhibition of MBP-fused Omi/HtrA2 (134 to 458 residues) (unknown origin) expressed in TB1 Escherichia coli at 20 to 100 uM pre-incubated for 40 mins to 1 hr before FITC-labeled dephosphorylated casein substrate addition and measured every 5 mins for 30 mins by fluorescence assay
Assay data:4 Tested
Inhibition of MBP-fused Omi/HtrA2 (134 to 458 residues) (unknown origin) expressed in TB1 Escherichia coli at 20 uM pre-incubated for 15 mins before FITC-labeled dephosphorylated casein substrate addition and measured every 5 mins for 30 mins by fluorescence assay relative to control
Assay data:2 Tested
Inhibition of MBP-fused Omi/HtrA2 (134 to 458 residues) (unknown origin) expressed in TB1 Escherichia coli at 20 to 100 uM pre-incubated for 15 mins before FITC-labeled dephosphorylated casein substrate addition and measured every 5 mins for 30 mins by fluorescence assay
Assay data:4 Active, 4 Tested
Inhibition of Omi/HtrA2 (unknown origin)-induced caspase-independent apoptosis in caspase 9 (-/-) fibroblasts transfected with Omi-GFP up to 10 uM incubated for 36 hrs by propidium iodide and 4',6-diamidino-2-phenylindole staining based fluorescence microscopy relative to control
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Summary
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced TNF-alpha response in human macrophages_Secondary screen TNF readout
Assay data:731 Active, 3462 Tested
SummaryRelated BioAssays by Same Project
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced TNF-alpha response in human macrophages_Primary screen TNF readout
Assay data:2853 Active, 18113 Tested
A screen to identify synthetic lethal interactions with E-cadherin in an MCF10A isogenic cell line
Assay data:2442 Active, 18052 Tested
SummaryPubMed Citation
A screen to identify genes that regulate lymphatic endothelial cell migration - Primary Screen
Assay data:1034 Active, 18120 Tested
SummaryRelated BioAssays by Depositor
Identification of proteins required for the processing of the EWS-FLI1 nascent transcript
Assay data:59220 Tested
InfectX: Pathogen infection siRNA screens
Assay data:115372 Tested
A whole genome RNAi screen highlights components of the ER/Golgi as a prominent source of resistance to immunotoxin-mediated cytotoxicity
Assay data:555 Active, 64752 Tested
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