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Inhibition of COX2 in rat macrophages using arachidonic acid as substrate preincubated with compound for 30 mins followed by substrate addition and measured after 20 mins by EIA
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryRelated BioAssays by Target
Inhibition of COX-2 in LPS/hypoxia induced rat H9c2 cells using arachidonic acid as substrate incubated for 5 mins by microplate reader method
Assay data:2 Active, 2 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
In vivo inhibition of COX2 in ip dosed orthotopic Sprague-Dawley rat model inoculated with C6 cells assessed as reduction in PGE2 production by ELISA
Assay data:2 Active, 3 Tested
In vivo inhibition of COX2 in Wistar rat assessed as reduction in formalin-induced COX2 expression at 10 mg/kg, ip incubated for 30 mins followed by formalin addition and measured after 2 hrs by immunofluorescence based assay
Inhibition of COX2 isolated from rat seminal vesicles assessed as reduction of PGG2 to PGH2 using arachidonic acid substrate preincubated for 15 mins followed by substrate addition
Assay data:4 Active, 2 Activity ≤ 1 µM, 4 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of rat kidney microsomal COX assessed as PGE2 level using arachidonic acid as substrate preincubated for 5 to 15 mins followed by substrate addition measured after 40 mins by radio immunoassay
Assay data:10 Active, 10 Activity ≤ 1 µM, 10 Tested
Inhibition of COX-2 in rat peritoneal macrophages assessed as reduction in PGE2 production using radiolabelled-arachidonic acid as substrate pretreated for 30 mins followed by substrate addition measured after 30 mins
Assay data:10 Active, 6 Activity ≤ 1 µM, 19 Tested
Inhibition of COX-mediated PGD2/PGE2 production in arachidonic acid-stimulated RBL1 cells preincubated for 2 hrs followed by A23187 induction for 15 mins by LC/MS/MS analysis
Assay data:11 Active, 1 Activity ≤ 1 µM, 13 Tested
Inhibition of COX-mediated PGD2/PGE2 production in arachidonic acid-stimulated RBL1 cells at 10 nM preincubated for 2 hrs followed by A23187 induction for 15 mins by LC/MS/MS analysis relative to control
Assay data:2 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of COX-mediated PGD2/PGE2 production in arachidonic acid-stimulated RBL1 cells at 10 uM preincubated for 2 hrs followed by A23187 induction for 15 mins by LC/MS/MS analysis relative to control
Assay data:74 Tested
Inhibition of COX in RBL1 cells assessed as reduction in PGE2/D2 production using A23187-induced arachidonic acid as substrate preincubated for 2 hrs followed by A23187 addition measured after 15 mins by LC-MS/MS analysis
Assay data:1 Active, 1 Activity ≤ 1 µM, 7 Tested
Inhibition of COX2 in rat abdominal macrophages assessed as PGE2 production pretreated for 30 mins followed by addition of 10 uM arachidonic acid as substrate for 20 mins by EIA
Assay data:30 Active, 30 Activity ≤ 1 µM, 30 Tested
Inhibition of cyclooxygenase in rat RBL1 cells
Assay data:18 Active, 7 Activity ≤ 1 µM, 52 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition of COX2 in rat synovial fibroblast assessed as inhibition of IL-1-mediated PGE2 production
Assay data:1 Tested
Inhibition of COX2 in rat whole blood assessed as decreased PGE2 production
Inhibition of COX-2 in LPS-stimulated rat leukocytes assessed as reduction in PGE2 production from arachidonic acid at 10 nM preincubated for 10 mins by EIA
Assay data:2 Active, 4 Tested
Inhibition of COX2 in LPS-stimulated rat microglia assessed as PGE2 release after 24 hrs by enzyme immunoassay
Inhibition of COX2 in LPS-stimulated rat microglia after 24 hrs by immunoblotting
Assay data:1 Active, 1 Tested
Percent reversal of FCA-induced arthritis in rats at 10 mg/kg
Assay data:10 Tested
Percentage inhibition of rat carrageenan-induced paw edema after iv administration at 3 mg/kg
Assay data:3 Tested
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