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GABAA, Muscimol, Central Eurofins Panlabs panel
Assay data:1 Tested
SummaryRelated BioAssays by Target
GABAA, Flunitrazepam, Central Eurofins Panlabs panel
GABAA, Chloride Channel, TBOB Eurofins Panlabs panel
BZD/CENTR/R Eurofins SafetyScreen44 (BI)
Displacement of [35S]-TBPS GABAA receptor in Wistar rat brain membrane incubated for 60 mins by competitive binding assay
Assay data:4 Active, 3 Activity ≤ 1 µM, 4 Tested
Displacement of [35S]-TBPS from rat synaptosomes GABAA receptor incubated for 90 mins by liquid scintillation counting method
Assay data:5 Active, 5 Activity ≤ 1 µM, 5 Tested
Positive allosteric modulation of rat recombinant GABAA alpha6beta3gamma2 receptor expressed in Xenopus laevis oocytes assessed as potentiation of GABA-induced response under more potent current at -80 mV holding potential at 30 uM in presence of GABA EC1 to 1.5 by two-electrode voltage-clamp assay
Positive allosteric modulation of rat recombinant GABAA alpha6beta3gamma2 receptor expressed in Xenopus laevis oocytes assessed as potentiation of GABA-induced response under more potent current at -80 mV holding potential at 100 nM in presence of GABA EC1 to 1.5 by two-electrode voltage-clamp assay
Positive allosteric modulation of rat recombinant GABAA alpha6beta3alpha1-gamma2beta3 receptor expressed in Xenopus laevis oocytes assessed as maximal efficacy at -80 mV holding potential at 30 uM in presence of GABA EC1 to 1.5 by two-electrode voltage-clamp assay
Assay data:5 Tested
Positive allosteric modulation of rat recombinant GABAA alpha6beta3alpha1-gamma2beta3 receptor expressed in Xenopus laevis oocytes assessed as maximal efficacy at -80 mV holding potential at 10 uM in presence of GABA EC1 to 1.5 by two-electrode voltage-clamp assay
Positive allosteric modulation of rat recombinant GABAA alpha6beta3alpha1-gamma2beta3 receptor expressed in Xenopus laevis oocytes assessed as maximal efficacy at -80 mV holding potential at 3 uM in presence of GABA EC1 to 1.5 by two-electrode voltage-clamp assay
Positive allosteric modulation of rat recombinant GABAA alpha6beta3alpha1-gamma2beta3 receptor expressed in Xenopus laevis oocytes assessed as maximal efficacy at -80 mV holding potential at 1 uM in presence of GABA EC1 to 1.5 by two-electrode voltage-clamp assay
Positive allosteric modulation of rat recombinant GABAA alpha6beta3alpha1-gamma2beta3 receptor expressed in Xenopus laevis oocytes assessed as maximal efficacy at -80 mV holding potential at 300 nM in presence of GABA EC1 to 1.5 by two-electrode voltage-clamp assay
Assay data:4 Tested
Positive allosteric modulation of rat recombinant GABAA alpha6beta3alpha1-gamma2beta3 receptor expressed in Xenopus laevis oocytes assessed as maximal efficacy at -80 mV holding potential at 100 nM in presence of GABA EC1 to 1.5 by two-electrode voltage-clamp assay
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