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Inhibition of USP25 (unknown origin) using ubiquitin rhodamine 110 as substrate at 1 to 10 uM by DUBprofiler fluorometric assay
Assay data:2 Tested
SummaryRelated BioAssays by Target
Inhibition of USP25 (unknown origin) using Ub-Rho100 as substrate by calorimetric analysis
Assay data:2 Active, 2 Activity ≤ 1 µM, 3 Tested
Inhibition of USP25 (unknown origin) at 10 uM using ubiquitin-rhodamine 110 as substrate preincubated for 30 mins followed by substrate addition and measured after 2 hrs by microplate spectrophotometer analysis
Assay data:6 Tested
SummaryPubMed CitationRelated BioAssays by Target
Biochemical Assay from US Patent US11325917: "Thienopyrazine carboxamides as ubiquitin-specific protease inhibitors"
Assay data:17 Active, 2 Activity ≤ 1 µM, 17 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Biochemical Assay from US Patent US10913753: "Thienopyridine carboxamides as ubiquitin-specific protease inhibitors"
Assay data:170 Active, 22 Activity ≤ 1 µM, 183 Tested
Biochemical Assay from US Patent US10889592: "Thienopyrazine carboxamides as ubiquitin-specific protease inhibitors"
Inhibition of USP25 (unknown origin) at 20 uM
Inhibition of USP25 (unknown origin) at 10 uM relative to control
Inhibition of human GST-tagged USP25 expressed in Escherichia coli assessed as cleavage of Ubiquitin-Rhodamine110-glycine to Ubiquitin and Rhodamine110-glycine using Ubiquitin-Rhodamine110-glycine as substrate by fluorescence based analysis
Assay data:1 Tested
Inhibition of recombinant C-terminal 6-His tagged human USP25 using ubiquitin-rhodamine 110 as substrate preincubated for 30 mins followed by substrate addition and measured after 45 mins by fluorescence based assay
Assay data:187 Active, 124 Activity ≤ 1 µM, 223 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Assay data:17 Active, 10 Activity ≤ 1 µM, 21 Tested
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Summary
Inhibition of recombinant human His6-tagged USP25 expressed in baculovirus infected Sf21 insect cells using Ub-Rh110 as substrate pretreated for 30 mins followed by substrate addition measured after 45 mins by fluorescence assay
Assay data:5 Active, 2 Activity ≤ 1 µM, 8 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced TNF-alpha response in human macrophages_Primary screen TNF readout
Assay data:2853 Active, 18113 Tested
SummaryRelated BioAssays by Same Project
A screen to identify genes that regulate endothelial cell migration - TertiaryScreen
Assay data:111 Active, 153 Tested
A screen to identify genes that regulate endothelial cell migration - Morphology analysis
Assay data:153 Tested
A screen to identify synthetic lethal interactions with E-cadherin in an MCF10A isogenic cell line
Assay data:2442 Active, 18052 Tested
SummaryPubMed Citation
A screen to identify genes that regulate lymphatic endothelial cell migration - Secondary Screen
Assay data:340 Active, 500 Tested
SummaryRelated BioAssays by Depositor
A screen to identify genes that regulate lymphatic endothelial cell migration - Primary Screen
Assay data:1034 Active, 18120 Tested
Identification of proteins required for the processing of the EWS-FLI1 nascent transcript
Assay data:59220 Tested
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