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Binding affinity to Granzyme A in human NK92 cells at 1 uM treated 1 hr after GrA covalent inhibitor methyl 4-[(3S)-3-[[2-[(2S)-2-[(1-diphenoxyphosphoryl-4-guanidinobutyl)carbamoyl]-2,3,3a,4,5,6,7,7a-octahydroindol-1-yl]-2-oxoethyl]carbamoyl]-3,4-dihydro-1H-isoquinolin-2-yl]-4-oxobutanoate dosing and measured 30 mins to 2 hrs post dose by SDS-PAGE analysis
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Binding affinity to Granzyme A in human NK92 cells at 1 uM measured 30 mins to 2 hrs post dose by SDS-PAGE analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Binding affinity to Granzyme A in human NK92 cells at 250 nM to 2 uM incubated for 1 hr by SDS-PAGE based in-gel detection assay
Binding affinity to Granzyme A zymogen form (unknown origin) expressed in Pichia pastoris at 500 nM in presence of 1 uM compound 3 by Western blot analysis
Binding affinity to Granzyme A active form (unknown origin) expressed in Pichia pastoris at 500 nM in presence of 1 uM methyl 4-[(3S)-3-[[2-[(2S)-2-[(1-diphenoxyphosphoryl-4-guanidinobutyl)carbamoyl]-2,3,3a,4,5,6,7,7a-octahydroindol-1-yl]-2-oxoethyl]carbamoyl]-3,4-dihydro-1H-isoquinolin-2-yl]-4-oxobutanoate by Western blot analysis
Binding affinity to Granzyme A zymogen form (unknown origin) expressed in Pichia pastoris by Western blot analysis
Binding affinity to Granzyme A active form (unknown origin) expressed in Pichia pastoris by Western blot analysis
Binding affinity to Granzyme A (unknown origin) expressed in Pichia pastoris assessed as minimum concentration needed for GrA labeling at enzyme to probe ratio was 1:1 incubated for 5 to 30 mins by SDS-PAGE based in-gel detection method
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Binding affinity to Granzyme A (unknown origin) expressed in Pichia pastoris assessed as appearance of fluorescent 35 kDa species at enzyme to probe ratio was 1:1 incubated for 5 mins by SDS-PAGE based in-gel detection method
Inhibition of Granzyme A (unknown origin) expressed in Pichia pastoris using SK15 substrate by spectrofluorometry relative to control
Assay data:2 Tested
Inhibition of Granzyme A (unknown origin) expressed in Pichia pastoris assessed as second- order inhibition rate constant (Kobs/I ratio) pre-incubated with SK15 substrate for 15 mins before enzyme addition by spectrofluorometry
Substrate activity at Granzyme A (unknown origin) expressed in Pichia pastoris incubated for 30 mins by fluorescence based assay
Assay data:11 Active, 13 Tested
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Summary
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced TNF-alpha response in human macrophages_Primary screen TNF readout
Assay data:2853 Active, 18113 Tested
SummaryRelated BioAssays by Same Project
A screen to identify synthetic lethal interactions with E-cadherin in an MCF10A isogenic cell line
Assay data:2442 Active, 18052 Tested
SummaryPubMed Citation
A screen to identify genes that regulate lymphatic endothelial cell migration - Primary Screen
Assay data:1034 Active, 18120 Tested
SummaryRelated BioAssays by Depositor
Identification of proteins required for the processing of the EWS-FLI1 nascent transcript
Assay data:59220 Tested
InfectX: Pathogen infection siRNA screens
Assay data:115372 Tested
A whole genome RNAi screen highlights components of the ER/Golgi as a prominent source of resistance to immunotoxin-mediated cytotoxicity
Assay data:555 Active, 64752 Tested
A screen to identify the genes that modify the response of osteosarcoma to doxorubicin in mouse - Primary Screen
Assay data:788 Active, 16789 Tested
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