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Inhibition of human HGPRT using PRib-PP as substrate at 90 uM by spectrophotometric assay
Assay data:2 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of human HGPRT using PRib-PP as substrate by spectrophotometric assay
Assay data:19 Active, 12 Activity ≤ 1 µM, 20 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Growth Inhibition Assay from US Patent US9200020: "6-oxopurine phosphoribosyltransferase inhibitors"
Assay data:10 Active, 6 Activity ≤ 1 µM, 13 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Spectrophotometric Assay from US Patent US9200020: "6-oxopurine phosphoribosyltransferase inhibitors"
Assay data:12 Active, 11 Activity ≤ 1 µM, 12 Tested
Inhbition Assay from Article 10.1016/j.chembiol.2012.04.012: "Acyclic Immucillin Phosphonates: Second-Generation Inhibitors of Plasmodium falciparum Hypoxanthine- Guanine-Xanthine Phosphoribosyltransferase."
Assay data:2 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of human HGPRT at 46 uM
Assay data:1 Tested
Competitive inhibition of human HGPRT by Morrison method
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
Inhibition of human HGPRT using PRib-PP as substrate by Hanes-plot based method
Assay data:6 Active, 4 Activity ≤ 1 µM, 12 Tested
Inhibition of human N-terminal His6-tagged HGPRT using Prib-PP as substrate by Hanes-plot based method
Assay data:2 Active, 1 Activity ≤ 1 µM, 3 Tested
Inhibition of human HGPRT assessed as inhibitor constant for enzyme-inhibitor-substrate complex formation using [5'-14C]IMP as substrate by scintillation counting method
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of human HGPRT assessed as inhibitor constant for enzyme-inhibitor complex formation using [5'-14C]IMP as substrate by scintillation counting method
Inhibition of human HGPRT using Prib-PP as substrate by Hanes-plot based method
Assay data:5 Active, 4 Activity ≤ 1 µM, 7 Tested
Assay data:6 Active, 2 Activity ≤ 1 µM, 10 Tested
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Summary
Inhibition of N-terminal hexa-histidine-tagged human HGPRT at 42 uM using PRib-PP as substrate in presence of guanine by spectrophotometric analysis
Inhibition of N-terminal hexa-histidine-tagged human HGPRT at 35 uM using PRib-PP as substrate in presence of guanine by spectrophotometric analysis
Inhibition of N-terminal hexa-histidine-tagged human HGPRT using PRib-PP as substrate in presence of guanine by Hanes plot analysis
Assay data:9 Active, 4 Activity ≤ 1 µM, 11 Tested
Inhibition of human HGPRT using PRib-PP as the substrate by spectrophotometric method
Assay data:10 Active, 7 Activity ≤ 1 µM, 10 Tested
Inhibition of recombinant human HGPRT using fixed concentration of guanine and variable concentrations of PRib-PP as substrate by Hanes plot analysis
Inhibition of human HGPRT using fixed concentration of guanine and variable concentrations of PRib-PP as substrate by spectrophotometric analysis
Assay data:4 Active, 1 Activity ≤ 1 nM, 4 Activity ≤ 1 µM, 6 Tested
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