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Binding affinity to 5-HT1F (unknown origin) assessed as inhibition constant
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Binding affinity to human 5-HT1F assessed as inhibition constant
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Binding affinity to human 5-HT1F assessed as inhibition constant incubated for 10 mins by radioligand binding assay
PRESTO-Tango GPCRome screening (HTR1F)
Assay data:1 Tested
SummaryRelated BioAssays by Target
5-HT1 Eurofins-Panlabs ligand profiling
Potency index, ratio of lasmiditan EC50 to test compound EC50 for agonist activity at 5HT1F receptor (unknown origin) expressed in HEK293 cells measured after 60 mins by Fluo-4AM dye based FLIPR assay
Assay data:5 Tested
SummaryPubMed CitationRelated BioAssays by Target
Binding affinity to human 5HT1F receptor
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
Agonist activity at 5HT1F receptor (unknown origin) expressed in HEK293 cells measured after 60 mins by Fluo-4AM dye based FLIPR assay
Assay data:11 Active, 11 Activity ≤ 1 µM, 12 Tested
Antagonist activity at serotonin receptor in human PBMC assessed as inhibition of PMA-stimulated superoxide anion generation at 10 uM preincubated for 1 hr followed by PMA-stimulation and measured after 30 mins by spectrophotometric method
Assay data:2 Active, 4 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Summary
Binding affinity to human 5-HT1F receptor
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
Displacement of [3H]BRL 43694 from human recombinant 5-HT3 receptor at 10 uM after 120 mins by scintillation counting analysis relative to control
Human 5-HT1F receptor (5-Hydroxytryptamine receptors)
Assay data:40 Active, 40 Tested
Activity at human 5HT1F receptor
Binding affinity to 5-HT receptor (unknown origin)
Assay data:1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Antagonist activity at 5-HT1F receptor (unknown origin) expressed in CHO cells assessed as calcium mobilization at 3 uM
Agonist activity at 5-HT1F receptor (unknown origin) expressed in CHO cells assessed as calcium mobilization at 3 uM
Agonist activity at human 5HT1F receptor expressed in LM(tk-) cells by [35S]GTPgammaS binding assay relative to 5-HT
Assay data:3 Tested
Agonist activity at human 5HT1F receptor expressed in LM(tk-) cells by [35S]GTPgammaS binding assay
Binding affinity to human 5HT1F receptor by radioligand binding assay
Assay data:13 Active, 8 Activity ≤ 1 µM, 14 Tested
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