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Cyp11 Assay from US Patent US9725436: "Cytochrome P450 inhibitors and their method of use"
Assay data:16 Active, 11 Activity ≤ 1 µM, 17 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Binding affinity to bovine CYP11A1 by spectral binding study
Assay data:1 Active, 1 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Binding affinity to active site of bovine CYP11A1 assessed as induction of type-II spectral response by spectral binding study
Drug metabolism assessed as bovine CYP11A1-mediated compound metabolism after 2 mins incubation using compound loaded phospholipid vesicle by reverse phase HPLC
Assay data:2 Tested
SummaryPubMed CitationRelated BioAssays by Target
Mechanism based inhibition of bovine cytochrome P450 CYP11A1
Assay data:1 Tested
Inhibition of bovine adrenal cholesterol side chain cleavage(CSCC) cytochrome P450 11A1
Assay data:13 Tested
Inhibition of P450 scc
Assay data:1 Active, 1 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of P450 scc at 25 uM
Inhibition of bovine adrenal desmolase at 50 ug/mL; None
Assay data:3 Tested
Inhibition of bovine adrenal desmolase cytochrome P450 11A1 at 50 ug/mL
Inhibition of bovine adrenal desmolase (IC50) relative to aminoglutethimide
Inhibition of bovine adrenal desmolase at 25 uM
Assay data:5 Tested
Percent inhibition of Bovine Adrenal Desmolase in vitro; inhibition values ranging from +5 to -5
Assay data:4 Tested
Percent inhibition of Bovine Adrenal Desmolase in vitro using bovine adrenal mitochondria and cholesterol; Inhibition values ranging from +5 to -5
Percent inhibition of Bovine Adrenal Desmolase in vitro (10.9 mg/kg); inhibition values ranging from +5 to -5
Evaluated for percent inhibition of Bovine Adrenal Desmolase in vitro using bovine adrenal mitochondria and cholesterol
Inhibition of bovine adrenal desmolase
Competitive inhibition constant (Km) for bovine cholesterol side-chain cleavage desmolase cytochrome P450 11A1
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of bovine cholesterol side-chain cleavage desmolase, cytochrome P450 11A1
Inhibition of bovine cholesterol side-chain cleavage desmolase, cytochrome P450 11A1; none
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