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Inhibition of human SHIP2 catalytic domain (419 to 832 residues) phosphatase activity assessed as phosphate release using Ins(1,3,4,5)P4 as substrate at 250 microM incubated for 20 mins measured using microplate reader
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of human SHIP2 (419 to 732 residues) expressed in Escherichia coli by malachite green phosphate assay
Assay data:3 Active, 2 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of human SHIP2 catalytic domain (419 to 832 residues) phosphatase activity assessed as phosphate release using Ins(1,3,4,5)P4 as substrate at 1 mM incubated for 20 mins measured using microplate reader
Assay data:2 Active, 2 Tested
Inhibition of human SHIP2 catalytic domain (419 to 832 residues) phosphatase activity assessed as inhibition of Ins(1,3,4,5)P4 production using Ins(1,3,4,5)P4 as substrate incubated for 20 mins measured using microplate reader
Assay data:7 Active, 2 Activity ≤ 1 µM, 11 Tested
Inhibition of human SHIP2 catalytic domain (419 to 832 residues) phosphatase activity assessed as phosphate release using Ins(1,3,4,5)P4 as substrate incubated for 20 mins measured using microplate reader
Assay data:6 Active, 1 Activity ≤ 1 µM, 11 Tested
Inhibition of 2-FAM-InsP5 binding to human SHIP2 catalytic domain (419 to 832 residues) assessed as change in polarization by fluorescence polarization based displacement assay
Assay data:10 Active, 5 Activity ≤ 1 µM, 15 Tested
Inhibition Assay from US Patent US9522881: "Hydroxyindole carboxylic acid based inhibitors for oncogenic Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2)"
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Assay data:39 Active, 12 Activity ≤ 1 µM, 48 Tested
PTP Assay from US Patent US9844535: "SHP2 inhibitors and methods of treating autoimmune and/or glomerulonephritis-associated diseases using SHP2 inhibitors"
Assay data:26 Active, 12 Activity ≤ 1 µM, 27 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Substrate activity at recombinant human N-terminal His-tagged SHIP2 (419 to 832 residues) expressed in Escherichia coli Rosetta2 (DE3) cells assessed as 1,3-Di-OH-Bz(2,4)P2 product formation at 100 uM incubated for 2 hrs in presence of AS1949490 by fluorescence based HPLC analysis
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Substrate activity at recombinant human N-terminal His-tagged SHIP2 (419 to 832 residues) expressed in Escherichia coli Rosetta2 (DE3) cells assessed as 1,2-diOH-Bz(3,4)P2 product formation at 100 uM incubated for 2 hrs in presence of AS1949490 by fluorescence based HPLC analysis
Substrate activity at recombinant human N-terminal His-tagged SHIP2 (419 to 832 residues) expressed in Escherichia coli Rosetta2 (DE3) cells assessed as 3-OH-Bz(1,2,4)P3 product formation at 100 uM incubated for 2 hrs in presence of AS1949490 by fluorescence based HPLC analysis
Substrate activity at recombinant human N-terminal His-tagged SHIP2 (419 to 832 residues) expressed in Escherichia coli Rosetta2 (DE3) cells assessed as 5-OH-Bz(1,2,4)P3 product formation at 100 uM incubated for 2 hrs in presence of AS1949490 by fluorescence based HPLC analysis
Substrate activity at recombinant human N-terminal His-tagged SHIP2 (419 to 832 residues) expressed in Escherichia coli Rosetta2 (DE3) cells assessed as 5-OH-Bz(1,2,4)P3 product formation at 100 uM incubated for 2 hrs in presence of INS(1,3,4,5)P4 by fluorescence based HPLC analysis
Substrate activity at recombinant human N-terminal His-tagged SHIP2 (419 to 832 residues) expressed in Escherichia coli Rosetta2 (DE3) cells assessed as 5-OH-Bz(1,2,4)P3 product formation at 100 uM incubated for 2 hrs by fluorescence based HPLC analysis
Substrate activity at recombinant human N-terminal His-tagged SHIP2 (419 to 832 residues) expressed in Escherichia coli Rosetta2 (DE3) cells assessed as 5-OH-Bz(1,2,4)P3 product formation at 100 uM measured upto 4 hrs by fluorescence based HPLC analysis
Substrate activity at recombinant human N-terminal His-tagged SHIP2 (419 to 832 residues) expressed in Escherichia coli Rosetta2 (DE3) cells assessed as 5-OH-Bz(1,2,4)P3 product formation at 100 uM incubated for 2 hrs with 100 nM to 1 mM of SHIP2 by fluorescence based HPLC analysis
Substrate activity at recombinant human N-terminal His-tagged SHIP2 (419 to 832 residues) expressed in Escherichia coli Rosetta2 (DE3) cells assessed as 5-OH-Bz(1,2,4)P3 product formation at 100 uM incubated for 12 hrs by fluorescence based HPLC analysis
Inhibition of His-tagged SHIP2 (unknown origin) incubated for 5 mins using Ins(1,3,4,5)P4 as substrate by malachite green reagent based phosphate assay
Displacement of Ins(1,3,4,5)P4 from recombinant human N-terminal His-tagged SHIP2 (419 to 832 residues) expressed in Escherichia coli BL21 (DE3)
Assay data:2 Tested
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