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Potency index, ratio of retigabine EC50 to test compound EC50 for anticonvulsant activity in Kv7.2/Kv7.3 (unknown origin) channel expressed in CHO cells
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Activation of Kv7.2/Kv7.3 channel (unknown origin) expressed in CHO cells assessed as maximum current density measured after 24 hrs by whole cell patch clamp based electrophysiological method
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Activation of Kv7.2/Kv7.3 channel (unknown origin) expressed in CHO cells assessed as fold change in maximum current density measured after 24 hrs by whole cell patch clamp based electrophysiological method relative to control
Assay data:3 Tested
Activation of Kv7.2/Kv7.3 channel (unknown origin) expressed in CHO cells at + 80 mV assessed as leftward shift change in half activation potential measured after 24 hrs by whole cell patch clamp based electrophysiological method
Assay data:3 Active, 2 Activity ≤ 1 µM, 3 Tested
Activation of Kv7.2/Kv7.3 channel (unknown origin) expressed in CHO cells at -120 mV measured after 24 hrs by whole cell patch clamp based electrophysiological method
Activation of Kv7.2/Kv7.3 channel (unknown origin) expressed in CHO cells at -80 mV measured after 24 hrs by whole cell patch clamp based electrophysiological method
Assay data:3 Active, 3 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Activation of Kv7.2/Kv7.3 channel (unknown origin) expressed in CHO cells assessed as leftward shift change in half activation potential at 1 uM measured after 24 hrs by whole cell patch clamp based electrophysiological method
Activation of Kv7.2/Kv7.3 channel (unknown origin) expressed in CHO cells assessed as half activation potential measured after 24 hrs by whole cell patch clamp based electrophysiological method
Activation of Kv7.2/Kv7.3 channel (unknown origin) expressed in CHO cells assessed as slope of fluorescent signal by FluxOR fluorescent dye based assay
Assay data:2 Active, 3 Tested
Activation of Kv7.2/Kv7.3 channel (unknown origin) expressed in CHO cells assessed as slope of fluorescent signal at 10 uM by FluxOR fluorescent dye based assay
Assay data:29 Tested
Agonist activity at human KCNQ2 expressed in CHO cells assessed as increase in outward current at 10 uM at 50 mV in presence of ztz240 by patch clamp electrophysiology method
Assay data:1 Active, 1 Tested
Agonist activity at human KCNQ2 expressed in CHO cells assessed as increase in outward current at 10 uM at 50 mV by patch clamp electrophysiology method
Agonist activity at human KCNQ2/3 expressed in CHO cells assessed as increase in outward current at 10 uM by patch clamp electrophysiology method
Agonist activity at human KCNQ2 expressed in CHO cells assessed as increase in outward current at 0.3 to 10 uM at -90 to +60 mV by patch clamp electrophysiology method
Agonist activity at human KCNQ2 expressed in CHO cells assessed as increase in outward current at 50 mV by patch clamp electrophysiology method
Agonist activity at human KCNQ2 expressed in CHO cells assessed as fold increase in outward current at 10 uM at 50 mV by patch clamp electrophysiology method
Inhibition of KCNQ2/3 (unknown origin) at a holding potential -40 mV at 30 uM by whole cell patch clamp electrophysiology relative to control
Assay data:2 Tested
Activation of Kv7.2 channel (unknown origin) by thallium flux assay
Potency index, ratio of EC50 for retigabine to EC50 for test compound for agonist activity at Kv7.2 (unknown origin) assessed as shifting of voltage dependent activation to more negative potentials by SyncroPatch assay
Agonist activity at Kv7.2/3 (unknown origin) expressed in CHO cells co-expressing GFP
Assay data:4 Active, 2 Activity ≤ 1 µM, 4 Tested
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