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Kinase assay from US Patent US10774086: "GSK-3 inhibitors"
Assay data:44 Active, 28 Activity ≤ 1 nM, 44 Activity ≤ 1 µM, 44 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
In Vitro Fluorescence-Based Recombinant Tau Binding Assay from US Patent US11642413: "Compounds for degrading Tau protein aggregates and uses thereof"
Assay data:8 Active, 8 Activity ≤ 1 µM, 8 Tested
Inhibition of heparin-induced tau protein (unknown origin) aggregation at 100 uM incubated for 3 days by Thioflavin T fluorescence assay
Assay data:3 Tested
SummaryPubMed CitationRelated BioAssays by Target
Binding affinity to N-terminal His-tagged recombinant human Tau40 expressed in Escherichia coli Rosetta (DE3) assessed as dissociation constant incubated for 0.5 hrs by fluorescence polarization assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Binding affinity to tau K18 domain (unknown origin) assessed as cysteine labelling at 250 uM incubated for 18 hrs by 15N-HSQC NMR spectroscopy
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of tau K18 domain (unknown origin) assessed as inhibition of heparin-induced aggregation by measuring increase in brightness by transmission electron microscopy
Assay data:3 Active, 3 Tested
Inhibition of tau K18 domain (unknown origin) assessed as inhibition of heparin-induced aggregation by measuring reduction in intensity at 215 nm with random coil conformation by CD spectrometry
Covalent binding affinity to tau K18 domain monomer (unknown origin) assessed as labelling at Cys322 residue incubated for 24 hrs and measured following trypsin digestion by LC-MS/MS analysis
Assay data:2 Active, 2 Tested
Covalent binding affinity to tau K18 domain monomer (unknown origin) assessed as labelling at Cys291 residue incubated for 24 hrs and measured following trypsin digestion by LC-MS/MS analysis
Inhibition of tau K18 domain (unknown origin) assessed as inhibition of heparin-induced aggregation by measuring protein aggregation rate at 1000 uM by thioflavin-T fluorescence assay relative to control
Inhibition of tau K18 domain (unknown origin) assessed as inhibition of heparin-induced aggregation by measuring protein aggregation rate at 500 uM by thioflavin-T fluorescence assay relative to control
Inhibition of tau K18 domain (unknown origin) assessed as inhibition of heparin-induced aggregation by measuring protein aggregation rate at 250 uM by thioflavin-T fluorescence assay relative to control
Inhibition of tau K18 domain (unknown origin) assessed as inhibition of heparin-induced aggregation by measuring protein aggregation rate at 100 uM by thioflavin-T fluorescence assay relative to control
Inhibition of tau K18 domain (unknown origin) assessed as inhibition of heparin-induced aggregation by measuring protein aggregation rate at 50 uM by thioflavin-T fluorescence assay relative to control
Binding affinity to tau K18 domain (unknown origin) assessed as cysteine labelling efficiency by measuring free thiol ratio at 200 uM incubated for 24 hrs by Ellmans method relative to control
Assay data:7 Tested
Inhibition of tau K18 domain (unknown origin) assessed as inhibition of heparin-induced aggregation by measuring protein aggregation rate at 10 uM by thioflavin-T fluorescence assay relative to control
Assay data:15 Tested
Inhibition of Tau (unknown origin) expressed in Escherichia coli BL21 (DE3) at 10 uM relative to control
Inhibition of tau aggregation (unknown origin) at 20 uM relative to control
Assay data:8 Tested
Inhibition of tau depolymerization (unknown origin) transfected in H4 cells incubated for 20 to 24 hrs by LPECL assay
Assay data:3 Active, 15 Tested
Inhibition of tau (unknown origin) transfected in human H4 cells incubated for 20 to 24 hrs by LPECL assay
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