Warning: The NCBI web site requires JavaScript to function. more...
An official website of the United States government
The .gov means it's official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.
The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.
Enzyme Inhibition Assays (Assay 1) from US Patent US20230285340: "NEPRILYSIN INHIBITORS"
Assay data:52 Active, 26 Activity ≤ 1 nM, 52 Activity ≤ 1 µM, 52 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Neprilysin Inhibition Assay from US Patent US20230285340: "NEPRILYSIN INHIBITORS"
Assay data:7 Active, 7 Activity ≤ 1 µM, 7 Tested
Enzyme Inhibition Assay from US Patent US11547687: "Neprilysin inhibitors"
Assay data:59 Active, 25 Activity ≤ 1 nM, 59 Activity ≤ 1 µM, 59 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition of recombinant N-terminal 6His-tagged human neprilysin expressed in CHO cells at 300 uM using Mca-Arg-Pro-Pro-Gly-Phe-Ser-Ala-Phe-Lys(Dnp)-OH as substrate and measured by fluorescence based assay relative to control
Assay data:2 Tested
SummaryRelated BioAssays by Target
Inhibition of hGH-8His-NEP expressed in CHO cells preincubated for 15 mins followed by MCA-RPPGFDAFK-(Dnp)-OH peptide substrate addition by fluorescence spectrophotometric analysis
Assay data:1 Active, 1 Activity ≤ 1 µM, 4 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Enzyme Inhibition Assay from US Patent US10759813: "Neprilysin inhibitors"
Assay data:220 Active, 110 Activity ≤ 1 nM, 220 Activity ≤ 1 µM, 220 Tested
Enzyme Inhibition Assay from US Patent US10744104: "Neprilysin inhibitors"
Assay data:40 Active, 22 Activity ≤ 1 nM, 40 Activity ≤ 1 µM, 40 Tested
In Vitro Inhibiton Assay from US Patent US9163040: "Substituted bisphenyl butanoic phosphonic acid derivatives as NEP inhibitors"
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
Fluorescence Lifetime-Based Assay from US Patent US9006249: "Substituted aminobutyric derivatives as neprilysin inhibitors"
Assay data:13 Active, 4 Activity ≤ 1 nM, 13 Activity ≤ 1 µM, 13 Tested
In Vitro Inhibition Assay from US Patent US8877786: "Substituted carbamoylmethylamino acetic acid derivatives as novel NEP inhibitors"
Assay data:7 Active, 4 Activity ≤ 1 nM, 7 Activity ≤ 1 µM, 7 Tested
Fluorescence Lifetime-Based Assay from US Patent US9603819: "Substituted aminobutyric derivatives as neprilysin inhibitors"
Enzyme Inhibition Assays from US Patent US10130642: "Neprilysin inhibitors"
Assay data:63 Active, 36 Activity ≤ 1 nM, 63 Activity ≤ 1 µM, 64 Tested
Enzyme Inhibition Assay from US Patent US9593110: "Neprilysin inhibitors"
Assay data:168 Active, 101 Activity ≤ 1 nM, 168 Activity ≤ 1 µM, 168 Tested
Enzyme NEP Inhibition Assay from US Patent US10123984: "Neprilysin inhibitors"
Assay data:47 Active, 21 Activity ≤ 1 nM, 47 Activity ≤ 1 µM, 47 Tested
NEUTRALENDOP Eurofins-Panlabs selectivity data (BI)
Assay data:1 Tested
N_ENDOPEP Cerep selectivity data (BI)
Inhibition of NEP 24.11 (unknown origin) by fluorometric assay
Assay data:2 Active, 2 Activity ≤ 1 µM, 3 Tested
Inhibition of human NEP using MCA-RPPGFSAFK-Dnp-OH as substrate by fluorescence based analysis
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of NEP (unknown origin)
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Substrate activity at recombinant human NEP (Tyr52 to Trp750 residues) expressed in HEK293 cells assessed as compound half life by LC-MS analysis
Assay data:7 Tested
SummaryPubMed CitationRelated BioAssays by Target
Filters: Manage Filters
Your browsing activity is empty.
Activity recording is turned off.
Turn recording back on