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Inhibition Assay from US Patent US11608309: "Curcumin analogues as zinc chelators and their uses"
Assay data:4 Active, 2 Activity ≤ 1 µM, 8 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Inhibition of MMP-2 (unknown origin) using fTHP-15(FAM) as substrate at 10 uM
Assay data:9 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of MMP-2 (unknown origin) using fTHP-15(FAM) as substrate at 5 uM
Assay data:5 Tested
Inhibition of MMP-2 (unknown origin) using fTHP-15(FAM) as substrate
Assay data:4 Active, 2 Activity ≤ 1 µM, 4 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Prodrug conversion assessed as MMP-2 (unknown origin)-mediated drug release by measuring half life by HPLC analysis
Assay data:1 Tested
Selectivity interaction (MMPs panel (FRET assay)) EUB0000730a MMP2
SummaryRelated BioAssays by Target
Selectivity interaction (MMPs panel (enzymatic assay)) EUB0000729a MMP2
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Selectivity interaction (Lead profiling screen (Eurofins, enzymes, transporters, GPCRs, ion chanels)) EUB0000728a MMP2
Selectivity interaction (MMPs panel (Panlabs panel, Bayer)) EUB0000725a MMP2
Inhibition of recombinant human MMP2 at 100 nM
Inhibition of recombinant human MMP2 using MOCAc-Lys-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-NH2 as a substrate preincubated for 15 mins followed by substrate addition and measured after 60 mins by fluroscence based assay
Assay data:28 Active, 23 Activity ≤ 1 nM, 29 Activity ≤ 1 µM, 29 Tested
Inhibition of MMP2 (unknown origin) using Mca-PLGLDpaAR fluorescent substrate incubated for 2 hrs by microplate reader method
Assay data:2 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of MMP2 in human U2OS cells by peptide microarray-based fluorescence assay
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of MMP2 in human U2OS cells at 1 umol/L by peptide microarray-based fluorescence assay
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of MMP2 in human U2OS cells at 5 umol/L by peptide microarray-based fluorescence assay
Assay data:4 Tested
Inhibition of MMP-2 (unknown origin) by Fluorometric analysis
Inhibition of human MMP-2 using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 1 hr followed by susbstrate addition by fluorescent analysis
Inhibition of human MMP-2 expressed in Escherichia coli BL21(DE3) using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 30 mins followed by susbstrate addition by photon-counter spectrophotometer analysis
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
Inhibition of MMP-2 (unknown origin) expressed in Escherichia coli BL21(DE3) and measured for 2 mins by enzymatic assay
Inhibition of recombinant human MMP-2 for 3 hrs using colorimetric substrate by ELISA
Assay data:1 Active, 1 Activity ≤ 1 µM, 2 Tested
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