Warning: The NCBI web site requires JavaScript to function. more...
An official website of the United States government
The .gov means it's official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.
The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.
Reversal of MRP1-mediated doxorubicin resistance in human 2008/MRP1 cells assessed as relative fold by measuring doxorubicin IC50 at 1 uM after 5 days by Cell Titer-Glo luminescence assay relative to control
Assay data:2 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of MRP1 in human 2008/MRP1 cells assessed as reversal of doxorubicin resistance by measuring doxorubicin IC50 at 1 uM after 5 days by Cell Titer-Glo luminescence assay
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Calcein-AM Assay from Article 10.1111/cbdd.12811: "Design, synthesis, biological evaluation, NMR and DFT studies of structurally simplified trimethoxy benzamides as selective P-glycoprotein inhibitors: the role of molecular flatness."
Assay data:4 Active, 14 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of MRP1 (unknown origin) expressed in human 2008/MRP1 cells assessed as reversal of mitoxantrone resistance after 5 days by MTS/PMS assay
Assay data:4 Active, 3 Activity ≤ 1 µM, 4 Tested
Inhibition of MRP1 (unknown origin) expressed in human 2008/MRP1 cells assessed as reversal of doxorubicin resistance after 5 days by MTS/PMS assay
Assay data:2 Active, 13 Activity ≤ 1 µM, 14 Tested
Inhibition of NEM-GS-stimulated MRP1 ATPase activity (unknown origin) in presence of GSH
Assay data:1 Active, 4 Tested
Inhibition of ABCC1 (unknown origin) expressed in H69AR cells preincubated for 30 mins followed by calcein-AM addition measured at 60 secs time interval by fluorescence assay
Assay data:3 Active, 23 Tested
Inhibition of ABCC1 (unknown origin) expressed in H69AR cells assessed as reduction in daunorubicin accumulation after 180 mins by flow cytometry analysis
Assay data:4 Active, 1 Activity ≤ 1 µM, 5 Tested
Inhibition of ABCC1 mediated etoposide resistant in human 2008 cells
Assay data:1 Tested
Inhibition of MRP1 in human COR-L23/R cells assessed reduction in tritiated daunomycin efflux incubated for 2 hrs by radioactivity based assay
Assay data:1 Active, 1 Tested
Inhibition of human MRP1 transfected in human HEK293 cells assessed as inhibition of Calcein-AM efflux measured after 30 mins by FACS Calibur cytometric analysis
Assay data:8 Tested
Inhibition of human ABCC1-mediated multidrug resistance in MDCK2 cells assessed as potentiation of doxorubicin-induced cytotoxicity by measuring half maximal reversal concentration after 72 hrs by MTT assay
Assay data:1 Active, 5 Tested
Inhibition of human ABCC1 expressed in MDCK2 cells preincubated for 30 mins followed by calcein AM addition and measured every 60 secs for 60 mins by fluorescence assay
Assay data:9 Active, 15 Tested
Inhibition of human ABCC1 expressed in MDCK2 cells at 10 uM preincubated for 30 mins followed by calcein AM addition and measured every 60 secs for 60 mins by fluorescence assay
Assay data:4 Active, 13 Tested
Prodrug release in doxorubicin-resistant human HT-29 cells assessed as increase in NO level by measuring induction of MRP1 nitration in mitochondria at 5 uM incubated for 24 hrs by western blot analysis
Assay data:3 Active, 8 Tested
Prodrug release in human HT-29 cells assessed as increase in NO level by measuring induction of MRP1 nitration in mitochondria at 5 uM incubated for 24 hrs by western blot analysis
Assay data:4 Active, 8 Tested
Prodrug release in doxorubicin-resistant human HT-29 cells assessed as increase in NO level by measuring mitochondria associated MRP1 nitration mediated drug uptake at 5 uM incubated for 24 hrs by spectrofluorometric analysis
Prodrug release in human HT-29 cells assessed as increase in NO level by measuring mitochondria associated MRP1 nitration mediated drug uptake at 5 uM incubated for 24 hrs by spectrofluorometric analysis
Prodrug release in human HT-29 cells assessed as increase in NO level by measuring induction of MRP1 nitration in plasma membrane at 5 uM incubated for 24 hrs by western blot analysis
Assay data:6 Active, 6 Tested
Prodrug release in doxorubicin-resistant human HT-29 cells assessed as increase in NO level by measuring induction of MRP1 nitration in plasma membrane at 5 uM incubated for 24 hrs by western blot analysis
Filters: Manage Filters
Your browsing activity is empty.
Activity recording is turned off.
Turn recording back on