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Inhibition of full-length ovine COX-1 using arachidonic acid as substrate preincubated for 5 mins followed by substrate addition and measured after 2 mins by colorimetry
Assay data:2 Active, 1 Activity ≤ 1 µM, 10 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of full-length ovine COX-1 at 50 uM using arachidonic acid as substrate preincubated for 5 mins followed by substrate addition and measured after 2 mins by colorimetry relative to control
Assay data:24 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of full-length ovine COX-1 at 5 uM using arachidonic acid as substrate preincubated for 5 mins followed by substrate addition and measured after 2 mins by colorimetry relative to control
Inhibition of ovine COX-1 assessed as PGE2alpha production using arachidonic acid as substrate preincubated for 10 mins followed by substrate addition and measured after 2 mins by enzyme immunoassay
Assay data:4 Tested
Inhibition of ovine COX-1 using arachidonic acid as substrate measured every 60 sec for 10 mins by fluorescence based assay
Assay data:1 Tested
Inhibition of ovine COX-1 at 3.3 uM using arachidonic acid as substrate by colorimetric analysis
Inhibition of ovine COX-1 at 17.5 uM using arachidonic acid as substrate by colorimetric analysis
Assay data:8 Tested
Inhibition of ovine COX-1 preincubated for 10 mins followed by arachidonic acid addition for 2 mins
Binding affinity to ovine COX-1 assessed as change in gibbs free energy by isothermal titration calorimetry
Binding affinity to ovine COX-1 assessed as change in entropy by isothermal titration calorimetry
Binding affinity to ovine COX-1 assessed as change in enthalpy by isothermal titration calorimetry
Binding affinity to ovine COX-1 assessed as association constant at equilibrium by isothermal titration calorimetry
Inhibition of ovine COX-1 using arachidonic acid as substrate preincubated for 10 mins followed by substrate addition and measured after 2 mins by EIA
Assay data:7 Active, 6 Activity ≤ 1 µM, 25 Tested
COX Inhibition Assay from Article 10.3109/14756366.2010.550890: "Synthesis and biological evaluation of 2,5-disubstituted 1,3,4-oxadiazole derivatives with both COX and LOX inhibitory activity."
Assay data:5 Active, 2 Activity ≤ 1 µM, 8 Tested
In Vitro Cyclo-Oxygenase Inhibition Assay from Article 10.3109/14756360903179435: "3-arylidene-5-(4-isobutylphenyl)-2(3H)-furanones: a new series of anti-inflammatory and analgesic compounds having antimicrobial activity."
Assay data:4 Active, 4 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
COX Inhibitor Screening Assay from Article 10.1016/j.bioorg.2017.04.012: "Design & synthesis of novel oxazolone & triazinone derivatives and their biological evaluation as COX-2 inhibitors."
Assay data:15 Active, 15 Activity ≤ 1 µM, 15 Tested
Cyclooxygenase Inhibition Assay from Article 10.1016/j.bioorg.2017.04.002: "New 1,2-diaryl-4-substituted-benzylidene-5-4H-imidazolone derivatives: Design, synthesis and biological evaluation as potential anti-inflammatory and analgesic agents."
Assay data:9 Active, 7 Activity ≤ 1 µM, 9 Tested
In Vitro COX-1 and COX-2 Inhibitory Assay from Article 10.1016/j.bioorg.2017.03.012: "New hybrid molecules combining benzothiophene or benzofuran with rhodanine as dual COX-1/2 and 5-LOX inhibitors: Synthesis, biological evaluation and docking study."
Assay data:15 Active, 1 Activity ≤ 1 µM, 15 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
In Vitro Cyclooxygenase (COX) Inhibition Assay from Article 10.1016/j.bioorg.2016.12.008: "Design, synthesis and biological screening of some novel celecoxib and etoricoxib analogs with promising COX-2 selectivity, anti-inflammatory activity and gastric safety profile."
Assay data:24 Active, 2 Activity ≤ 1 µM, 25 Tested
COX Inhibition Assay from Article 10.1016/j.bioorg.2016.11.014: "In vivo anti-inflammatory activity and docking study of newly synthesized benzimidazole derivatives bearing oxadiazole and morpholine rings."
Assay data:2 Active, 1 Activity ≤ 1 µM, 19 Tested
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