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Activation of NF-kappaB (unknown origin) transfected in HEK293T cells at 0.4 to 10 uM incubated for 48 hrs by Dual-luciferase reporter gene assay
Assay data:1 Tested
SummaryRelated BioAssays by Target
Inhibition of TNF alpha stimulated NF-KappaB in HEK293 cells using luciferase as substrate pretreated with compound followed by stimulation of TNF alpha incubated for 6 hrs and measured after substrate addition by luciferase assay
Assay data:1 Active, 1 Tested
Inhibition of NF-kB (unknown origin)
Inhibition of TNF-alpha stimulated NF-kappa B (unknown origin) activation in transfected in human K562 cells preincubated with compound for 2 hrs followed by stimulation of TNF alpha and measured after 6 hrs
Inhibition of human NF-kappaB p65 binding to DNA in LPS-stimulated human keratinocytes at 7.5 uM for 30 mins by ELISA
Inhibition of TNF-alpha induced NFkappaB activation in HEK293 cells transfected with luciferase reporter gene preincubated with compound for 10 mins followed by TNF-alpha addition and measured after 6 hrs by luciferase based assay
Assay data:1 Active, 2 Tested
Inhibition of TNF-alpha induced NFkappaB activation in HEK293 cells at 100 uM pretreated for 15 mins followed by stimulation with human recombinant TNFalpha and measured after 6 hrs by luminescence based assay relative to control
Inhibition of NFkappaB in human Jurkat cells incubated for 30 mins by bright-glo luciferase assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of cisplatin-induced NF-kappaB activation in HUVEC cell nuclear extract assessed as reduction in NF-kappaB-DNA binding activity at 30 uM incubated for 1 hr in presence of eNOS inhibitor, N(G)-nitro-L-arginine methyl ester by electrophoretic mobility shift assay
Inhibition of cisplatin-induced NF-kappaB activation in HUVEC cell nuclear extract assessed as reduction in NF-kappaB-DNA binding activity at 30 uM incubated for 1 hr in presence of PI3K inhibitor, wortmannin by electrophoretic mobility shift assay
Inhibition of cisplatin-induced NF-kappaB activation in HUVEC cell nuclear extract assessed as reduction in NF-kappaB-DNA binding activity at 100 uM incubated for 1 hr by electrophoretic mobility shift assay
Inhibition of cisplatin-induced NF-kappaB activation in HUVEC cell nuclear extract assessed as reduction in NF-kappaB-DNA binding activity at 30 uM incubated for 1 hr by electrophoretic mobility shift assay
Inhibition of NF-kappaB phosphorylation in human HL-60 cells at 10 uM measured after 2 hrs by Immunoblotting analysis
Assay data:5 Active, 5 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Activation of NF-kappaB mediated pro-inflammatory effector proteins in human THP-1 cells at 2 to 10 nM incubated for 4 hrs by western blot analysis
Assay data:3 Active, 3 Tested
Inhibition of NF-kappaB activation in human HGC-27 cells assessed as downregulation of NF-kappaB phosphorylation at 10 uM for 48 hrs by DAPI staining based immunofluorescence assay
Inhibition of NF-kappaB activation in human RKO cells assessed as downregulation of NF-kappaB phosphorylation at 10 uM for 48 hrs by DAPI staining based immunofluorescence assay
Inhibition of NF-kappaB activation in human HT-29 cells assessed as reduction in TNFalpha-stimulated NF-kappaB nuclear translocation at 10 uM for 24 hrs followed by TNF- alpha stimulation for 1 hrs by DAPI staining based immunofluorescence assay
Inhibition of NF-kappaB (unknown origin)
Assay data:3 Active, 2 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of LPS induced NF-kappaB activation (unknown origin) assessed as relative luciferase activity
Assay data:5 Active, 5 Activity ≤ 1 µM, 5 Tested
Inhibition of NF kappa B activation (unknown origin)
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