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Binding Assay from US Patent US8916594: "5-membered ring heteroaromatic derivatives having NPY Y5 receptor antagonistic activity"
Assay data:2 Active, 2 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
PRESTO-Tango GPCRome screening (NPY5R)
Assay data:1 Tested
SummaryRelated BioAssays by Target
Displacement of [3H]propionyl-pNPY from human neuropeptide Y Y5 receptor in human HEC-1B cells measured after 90 mins by scintillation counting analysis
Assay data:2 Active, 6 Activity ≤ 1 µM, 21 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Allosteric antagonist activity at eFYP-tagged human NPY5R expressed in COS7 cells co-expressing Gqi5-alpha assessed as inhibition of NPY-induced Ca2+ flux at 30 uM by Fluo-2 AM dye based fluorescent assay
SummaryPubMed CitationRelated BioAssays by Target
Agonist activity at NPY5R (unknown origin) by CRE-luciferase reporter gene assay
Assay data:2 Active, 1 Activity ≤ 1 µM, 3 Tested
Displacement of [3H]propionyl-pNPY from human Y5 receptor expressed in human HEC1B cells
Assay data:6 Activity ≤ 1 µM, 30 Tested
SummaryCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Displacement of [3H]propionyl-pNPY from human NPY Y5 receptor expressed in human HEC1b cells after 120 mins by liquid scintillation counting
Assay data:10 Active, 8 Activity ≤ 1 µM, 11 Tested
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Summary
Positive allosteric modulation of human C-terminal eYFP-fused human NY5 receptor expressed in African green monkey COS7 cells co-expressing delta6Galphaqi4-myr assessed as potentiation of neuropeptide Y-mediated Ca2+ flux by measuring pancreatic polypeptide EC50 at 30 uM treated at 20 secs post baseline detection followed by addition of neuropeptide Y after 140 secs by Fluo2-AM fluorescent dye-based assay (Rvb = 8.5 +/- 0.1 No_unit)
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Activation of human Y5R expressed in HEK293 cells assessed as inhibition of isoproterenol-induced increase in intracellular cAMP levels by calcium 5 dye-based FLIPR assay
Assay data:19 Active, 20 Activity ≤ 1 µM, 20 Tested
Displacement of [125I]-PYY(1 to 36 residues) from human Y5R expressed in HEK293 cell membranes after 2 hrs by scintillation proximity assay
Assay data:43 Active, 4 Activity ≤ 1 nM, 34 Activity ≤ 1 µM, 43 Tested
Human Y5 receptor (Neuropeptide Y receptors)
Assay data:17 Active, 17 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Displacement of Cy5-pNPY from human NPY5R expressed in HEC cells by flow cytometric analysis
Assay data:7 Tested
Agonist activity at human neuropeptide Y Y5 receptor expressed in COS-7 cells cotransfected with chimeric Gi/q protein assessed as inositol phosphate accumulation at 1 uM after 2 hrs by anion exchange chromatography
Assay data:4 Tested
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced TNF-alpha response in human macrophages_Primary screen TNF readout
Assay data:2853 Active, 18113 Tested
SummaryRelated BioAssays by Same Project
Agonist activity at human NPY5 receptor at 100 uM to 5 mM
Assay data:30 Tested
A screen to identify synthetic lethal interactions with E-cadherin in an MCF10A isogenic cell line
Assay data:2442 Active, 18052 Tested
SummaryPubMed Citation
A screen to identify genes that regulate lymphatic endothelial cell migration - Primary Screen
Assay data:1034 Active, 18120 Tested
SummaryRelated BioAssays by Depositor
Identification of proteins required for the processing of the EWS-FLI1 nascent transcript
Assay data:59220 Tested
InfectX: Pathogen infection siRNA screens
Assay data:115372 Tested
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