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Inhibition of PAK2 (unknown origin) at 10 uM by biochemical hotspot kinase assay
Assay data:1 Tested
SummaryRelated BioAssays by Target
PROTAC activity at PAK2/CRBN in human OVACR-3 cells assessed as PAK1 degradation at 10 nM measured after 24 hrs by immunoblot analysis
PROTAC activity at PAK2/CRBN in human MCF7 cells assessed as PAK1 degradation at 10 nM measured after 24 hrs by immunoblot analysis
Inhibition of human recombinant full length PAK2 assessed as phosphorylation FRET peptide substrate measured after 60 mins
Assay data:1 Active, 1 Activity ≤ 1 µM, 2 Tested
Inhibition of human partial length wild type PAK2 (P151/R525) expressed in bacterial system at 1 uM by KINOMEscan analysis relative to control
Selectivity interaction (KinomeScan (DiscoverX)) EUB0000727a PAK2
Selectivity interaction (KinomeScan (DiscoverX, competition-binding assay)) EUB0000164c PAK2
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition of recombinant human PAK2 (3 to end residues) assessed as residual activity at 1 uM using KEAKEKRQEQIAKRRRLSSLRASTSKSGGSQK as substrate incubated for 40 mins in presence of [gamma-33P]-ATP by radiometric scintillation counting method relative to control
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of human PAK2 assessed as residual activity at 30 uM relative to control
Inhibition of human PAK2 at 1 uM by DiscoverX KINOMEscan assay relative to control
Inhibition of full length nanoLuc-tagged human PAK2 expressed in HEK293 cells using NanoBRET NanoGlo substrate incubated for 2 hrs in presence of tracer K10 by NanoBRET assay
Inhibition of human PAK2 by radiometric PanQinase activity assay
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of human PAK2 at 1 uM by radiometric PanQinase activity assay relative to control (Rvb=50%)
PAK2 DiscoveRx kinase panel
PAK2(h) Kinase panel
Inhibition of PAK2 (unknown origin) at 1 uM
Inhibition of PAK2 (unknown origin) assessed as residual activity at 10 uM in presence of [33P]gamma-ATP by radiometric filter binding assay
Inhibition of human recombinant PAK2 assessed as reduction in substrate phosphorylation at 50 to 500 nM using ATP and Ulight-CKKSRGDYMTMQIG (IRS-1) incubated for 60 min by LANCE detection method
Mobility Shift Assay from US Patent US9365572: "PI3K and/or mTOR inhibitor"
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
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