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hPD-1/hPD-L1 binding assay from US Patent US20240043392: "NOVEL BIPHENYL DERIVATIVE AND PREPARATION METHOD AND PHARMACEUTICAL USE THEREOF"
Assay data:22 Active, 22 Activity ≤ 1 µM, 22 Tested
SummaryRelated BioAssays by Target
Inhibition of PD-1/PD-L1 interaction (unknown origin) incubated for 24 hrs by HTRF assay
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
Inhibition of C-terminal his tagged human PD-1/human Fc tagged PDL-1 interaction expressed in HEK293 cells incubated for 2 hrs AlphaScreen assay
Assay data:2 Active, 1 Activity ≤ 1 µM, 6 Tested
Inhibition of PD-L1/PD-1 interaction in human BGC-823 cells assessed as decrease in binding of PD-1 to cell membrane at 5 to 20 uM incubated for 5 days followed by recombinant PD-1-Fc protein addition by confocal microscopy analysis
Assay data:1 Tested
Inhibition of PD-1/PD-L1 interaction in human MDA-MB-231 cells assessed as increase in mouse splenocytes proliferation
Assay data:6 Tested
Inhibition of recombinant human PD-1/PD-L1 interaction relative to control
Assay data:5 Tested
Inhibition of human PD-1 expressed in rat PBMCs/human PD-L1 expressed in MDA-MB-231 cells protein-protein interaction assessed as increase in PBMCs proliferation
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of human PD-1/PD-L1 interaction
Assay data:17 Active, 1 Activity ≤ 1 nM, 17 Activity ≤ 1 µM, 17 Tested
Inhibition of human PD-1/PDL1 protein-protein interaction by TR-FRET assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Binding affinity to human PD-1 assessed as dissociation constant by SPR assay
Inhibition of human PD-1/PDL1 protein-protein interaction by luminescence proximity homogeneous assay
Assay data:3 Active, 3 Tested
Inhibition of human PD-1/PDL1 protein-protein interaction
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
Inhibition of human PD-1/PDL1 protein-protein interaction by HTRF assay
Assay data:6 Active, 97 Activity ≤ 1 µM, 97 Tested
Homogeneous time resolved fluorescence (HTRF) from US Patent US20230390287: "MODULATORS OF PD-L1/PD-1 INTERACTION AND USES THEREOF"
Assay data:12 Active, 8 Activity ≤ 1 µM, 12 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Binding of PD-1 to PD-L1 Using Homogenous Time-Resolved Fluorescence (HTRF) Binding Assay from US Patent US20230365627: "MACROCYCLIC PEPTIDE BORONATE IMMUNOMODULATORS"
Assay data:39 Active, 39 Activity ≤ 1 µM, 39 Tested
In Vitro Inhibitory Activity Against PD-1/PD-L1 Binding from US Patent US20230365590: "BIPHENYL COMPOUND AS IMMUNOMODULATOR, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF"
Assay data:13 Active, 2 Activity ≤ 1 nM, 13 Activity ≤ 1 µM, 13 Tested
PD-1/PD-L1 Homogeneous Time-Resolved Fluorescence (HTRF) Binding Assay from US Patent US20230357219: "PREPARATION OF BIARYL RING-LINKED AROMATIC HETEROCYCLIC DERIVATIVE AS IMMUNOMODULATOR AND USE THEREOF"
Assay data:10 Active, 10 Activity ≤ 1 µM, 10 Tested
Homogenouse Time-Resolved Fluorescence Assay from US Patent US20230331675: "AROMATIC ETHYLENE COMPOUND AND PREPARATION METHOD THEREFOR, AND INTERMEDIATE, PHARMACEUTICAL COMPOSITION, AND APPLICATION THEREOF"
Assay data:70 Active, 2 Activity ≤ 1 nM, 67 Activity ≤ 1 µM, 78 Tested
Homogeneous Time-Resolved Fluorescence (HTRF) from US Patent US11787766: "Compound having PD-L1 inhibitory activity, preparation method therefor and use thereof"
Assay data:59 Active, 79 Activity ≤ 1 µM, 79 Tested
Interaction between Compound and Human PD-L1 Protein from US Patent US20230303494: "BENZYLAMINE DERIVATIVE, PREPARATION METHOD THEREFOR AND USE THEREOF"
Assay data:5 Active, 3 Activity ≤ 1 nM, 5 Activity ≤ 1 µM, 5 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
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