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Inhibition of PDE1 (unknown origin)
Assay data:2 Active, 2 Activity ≤ 1 µM, 3 Tested
SummaryRelated BioAssays by Target
Inhibition of human PDE1B
Assay data:1 Tested
Inhibition of recombinant full length PDE1B in human myocardium using cAMP as substrate
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of PDE1B (unknown origin)
Assay data:3 Active, 2 Activity ≤ 1 µM, 3 Tested
PDE1 Inhibition Assay from US Patent US11634416: "Combination treatments comprising administration of 1H-pyrazolo[4,3-b]pyridines"
Assay data:192 Active, 70 Activity ≤ 1 nM, 192 Activity ≤ 1 µM, 192 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition Assay from US Patent US11535611: "Pyrazolo[3,4-B]pyridines and imidazo[1,5-B]pyridazines as PDE1 inhibitors"
Assay data:85 Active, 70 Activity ≤ 1 µM, 85 Tested
PDE1 Inhibition Assay from US Patent US11491140: "1H-pyrazolo[4,3-b]pyridines as PDE1 inhibitors"
Assay data:196 Active, 73 Activity ≤ 1 nM, 196 Activity ≤ 1 µM, 196 Tested
Inhibition of PDE1B (10 to 487 residues) (unknown origin) expressed in Escherichia coli BL21 using [3H]-cGMP as substrate measured for 15 mins by liquid scintillation counter method
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of PDE1B (10 to 487 residues) (unknown origin) expressed in Escherichia coli BL21 using [3H-GMP] or [3H-AMP] as substrate incubated for 15 mins by liquid scintillation counting method
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of cAMP-specific 3',5'-cyclic phosphodiesterase (unknown origin)
Assay data:2 Active, 1 Activity ≤ 1 µM, 4 Tested
Inhibition of human PDE4 at 10 uM relative to control
Inhibition of PDE4 in human U-937 cells assessed as reduction in cAMP level by LANCE cAMP Assay
Assay data:8 Active, 8 Activity ≤ 1 nM, 8 Activity ≤ 1 µM, 8 Tested
Phosphodiesterase Enzyme Assay from US Patent US11453673: "Substituted [1,2,4]triazolo[4,3-a]pyrazines as phosphodiesterase inhibitors"
Assay data:16 Active, 1 Activity ≤ 1 nM, 16 Activity ≤ 1 µM, 16 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Enzyme Assays from US Patent US11401274: "[1,2,4]Triazolo derivatives as PDE1 inhibitors for the treatment of diabetes"
Assay data:8 Active, 8 Activity ≤ 1 µM, 8 Tested
Ca2+-Calmodulin Dependent PDE Enzyme Assays from US Patent US11180503: "[1,2,4]Triazolo[4,3-A]pyrazin-6(5H)-one derivatives"
Assay data:13 Active, 6 Activity ≤ 1 nM, 13 Activity ≤ 1 µM, 13 Tested
PDE1 Inhibition Assay from US Patent US11104680: "1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-ones and 1,5-dihydro-4H-pyrazolo[4,3-c]pyridin-4-ones as PDE1 inhibitors"
Assay data:27 Active, 27 Activity ≤ 1 µM, 27 Tested
Inhibition Assay from US Patent US11026923: "1H-pyrazolo[4,3-b]pyridines as PDE1 inhibitors"
Inhibition Assay from US Patent US10912773: "Combinations comprising substituted imidazo[1,5-a]pyrazinones as PDE1 inhibitors"
Assay data:107 Active, 102 Activity ≤ 1 µM, 107 Tested
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