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Inhibition of human PP-1cgamma expressed in Escherichia coli assessed as reduction in phosphatase activity by measuring release of inorganic phosphate at 83.3 uM using 5'-TAMRA-tagged 20-mer oligonucleotide as substrate incubated for 30 mins by fluorescence quenching based assay
Assay data:1 Tested
SummaryRelated BioAssays by Target
RNAi screen for vemurafenib enhancer genes in BRAFV600 melanoma - Primary Screen
Assay data:790 Active, 18119 Tested
Summary
Inhibition of recombinant PP1C gamma1-isoform (unknown origin) pre-incubated for 15 mins with enzyme before 32P-labeled MBP substrate addition
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Genome-wide siRNA screen of genes regulating the Lipopolysaccharide-induced TNF-alpha response in human macrophages_Primary screen TNF readout
Assay data:2853 Active, 18113 Tested
SummaryRelated BioAssays by Same Project
A screen to identify synthetic lethal interactions with E-cadherin in an MCF10A isogenic cell line
Assay data:2442 Active, 18052 Tested
SummaryPubMed Citation
A screen to identify genes that regulate lymphatic endothelial cell migration - Primary Screen
Assay data:1034 Active, 18120 Tested
SummaryRelated BioAssays by Depositor
Identification of proteins required for the processing of the EWS-FLI1 nascent transcript
Assay data:59220 Tested
InfectX: Pathogen infection siRNA screens
Assay data:115372 Tested
A whole genome RNAi screen highlights components of the ER/Golgi as a prominent source of resistance to immunotoxin-mediated cytotoxicity
Assay data:555 Active, 64752 Tested
RNAi screen for vorinostat resistance genes - Primary Screen
Assay data:450 Active, 18118 Tested
Druggable Genome siRNA Screen for Enhancers of Camptothecin in MDA-MB-231 Breast Cancer Cells
Assay data:167 Active, 26449 Tested
Genome-wide high-content siRNA screens for regulators of Parkin translocation in selective mitophagy (Ambion Library)
Assay data:9227 Active, 64752 Tested
Genome-wide high-content siRNA screens for regulators of Parkin translocation in selective mitophagy (Dharmacon Library)
Assay data:826 Active, 18119 Tested
An siRNA screen for human genes that are involved in human papilloma virus (HPV) E2 transcriptional repression of the E6 and E7 oncogenes
Assay data:497 Active, 21019 Tested
Inhibition of PP1gamma by firefly bioluminescence assay
Assay data:10 Active, 10 Activity ≤ 1 µM, 10 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibitory activity against Protein phosphatase 1 at 10 uM
Assay data:2 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibitory activity against Protein phosphatase 1
Assay data:2 Active, 1 Activity ≤ 1 µM, 3 Tested
Inhibition of Serine/threonine protein phosphatase 1 (PP1) mutant type E256R by compound was evalutade; ND means not determined.
Inhibition of Serine/threonine protein phosphatase 1 (PP1) mutant type E252A:D253A:E256R by compound was evalutade; ND means not determined.
Inhibition of Serine/threonine protein phosphatase 1 (PP1) mutant type E252A:D253A by compound was evalutade; ND means not determined.
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