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Binding affinity to human partial length PBRM1 bromodomain 5 (S645 to D766 residues) expressed in bacterial expression system by BROMOscan assay
Assay data:4 Tested
SummaryRelated BioAssays by Target
Binding affinity to human partial length PBRM1 bromodomain 1 (S178 to E291 residues) expressed in bacterial expression system by BROMOscan assay
Assay data:1 Active, 4 Tested
Selectivity interaction (Bromodomain panel (DSF assay)) EUB0000199c PBRM1
Assay data:1 Tested
Affinity Biochemical interaction (Isothermal titration calorimetry (ITC)) EUB0000199c PBRM1
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Affinity On-target Cellular interaction (FRAP assay in U2OS cells full-length PB1 protein) EUB0000199c PBRM1
Binding affinity to human PBRM1 bromodomain 2 (S178 to E291 residues) expressed in bacterial expression system by bromoscan assay
Assay data:5 Active, 3 Activity ≤ 1 µM, 5 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Binding affinity to human PBRM1 bromodomain 5 (S645 to D766 residues) expressed in bacterial expression system by bromoscan assay
Assay data:4 Active, 4 Activity ≤ 1 µM, 5 Tested
Inhibition of PBRM1 bromodomain 5 (unknown origin) by TR-FRET assay
Assay data:2 Active, 1 Activity ≤ 1 µM, 4 Tested
Binding affinity to N-terminal His-TEV-tagged human PBRM1 BD6 transfected in Escherichia coli BL21 (DE3) assessed as thermal stabilization by measuring change in melting temperature at 100 uM by SYPRO orange dye based differential scanning fluorimetry analysis
SummaryPubMed CitationRelated BioAssays by Target
Binding affinity to C-terminal His-TEV-FLAG-tagged human PBRM1 BD4 transfected in Escherichia coli BL21 (DE3) assessed as thermal stabilization by measuring change in melting temperature at 100 uM by SYPRO orange dye based differential scanning fluorimetry analysis
Binding affinity to His-TEV-tagged human PBRM1 BD1 transfected in Escherichia coli BL21 (DE3) assessed as thermal stabilization by measuring change in melting temperature at 100 uM by SYPRO orange dye based differential scanning fluorimetry analysis
Assay data:2 Tested
Binding affinity to His-TEV-tagged human PBRM1 BD3 transfected in Escherichia coli BL21 (DE3) assessed as thermal stabilization by measuring change in melting temperature at 100 uM by SYPRO orange dye based differential scanning fluorimetry analysis
Assay data:3 Tested
Inhibition of biotinylated histone H3 (1 to 30residues) peptide binding to full length PBRM1 in human LNCaP cells at 50 uM by immunoblot analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Binding affinity to His-TEV-tagged human PBRM1 BD5 transfected in Escherichia coli BL21 (DE3) assessed as thermal stabilization by measuring change in melting temperature at 100 uM by SYPRO orange dye based differential scanning fluorimetry analysis
Assay data:6 Tested
Binding affinity to His-TEV-tagged human PBRM1 BD5 transfected in Escherichia coli BL21 (DE3) assessed as dissociation constant at 30 uM by ITC analysis
Assay data:3 Active, 1 Activity ≤ 1 µM, 7 Tested
Inhibition of biotinylated histone H3K14/18/23/27Ac (1 to 30 residues) peptide binding to PBRM1 in human LNCaP cells at 50 uM by immunoblot analysis
Binding affinity to His-TEV-tagged recombinant human PBRM1 BD2 transfected in Escherichia coli BL21 (DE3) assessed as dissociation constant at 30 uM by ITC analysis
Assay data:6 Active, 1 Activity ≤ 1 µM, 7 Tested
Inhibition of biotinylated histone H3K14 (1 to 20 residues) peptide binding to His6-tagged recombinant human PBRM1 BD2 transfected in Escherichia coli BL21 (DE3) incubated for 30 mins by Alphascreen assay
Assay data:21 Active, 11 Activity ≤ 1 µM, 32 Tested
Binding affinity to 15N-labeled recombinant human PBRM1 BD2 transfected in Escherichia coli BL21 (DE3) assessed as thermal stabilization by measuring change in melting temperature at 100 uM by SYPRO orange dye based differential scanning fluorimetry analysis
Assay data:40 Tested
Binding affinity to 15N-labeled recombinant human PBRM1 BD2 transfected in Escherichia coli BL21 (DE3) assessed as 1H/13N chemical shift perturbation by measuring dissociation constant by NMR titration analysis
Assay data:12 Tested
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