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Activation of AMPK (unknown origin)
Assay data:1 Tested
SummaryRelated BioAssays by Target
Activation of human recombinant AMPK A2/B2/G1 assessed as increase in AMPK phosphorylation using FL-peptide as substrate incubated for 120 mins by EZ reader method
Assay data:10 Active, 7 Activity ≤ 1 µM, 12 Tested
Selectivity interaction (KinomeScan (DiscoverX)) EUB0000351a PRKAA2
Inhibition of recombinant AMPK A2/B1/G1 (unknown origin) at 0.1 uM relative to control
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of recombinant AMPK (A2/B1/G3) (unknown origin) at 0.1 uM relative to control
Assay data:14 Active, 2 Activity ≤ 1 nM, 14 Activity ≤ 1 µM, 15 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Activation of AMPK in human HepG2 cells assessed as reduction in mitochondrial ATP production incubated for 1 hr
Assay data:24 Active, 1 Activity ≤ 1 nM, 18 Activity ≤ 1 µM, 25 Tested
Activation of AMPK in human HepG2 cells assessed as increase in ACC phosphorylation at Ser79 incubated for 1 hr
Assay data:54 Active, 3 Activity ≤ 1 nM, 46 Activity ≤ 1 µM, 55 Tested
AMPK-alpha2 DiscoveRx kinase panel
AMPKalpha2(h) Kinase panel
Activation of AMPK pathway in human HCCLM3 cells assessed as increase in AMPK phosphorylation level at 5 nM measured after 1 hr by Western blot analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Selectivity Screening (AMPK) from US Patent US10981896: "Indolinone derivatives as inhibitors of maternal embryonic leucine zipper kinase"
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
enzyme-linked immunosorbent assay from US Patent US10377742: "AMPK-activating heterocyclic compounds and methods for using the same"
Assay data:457 Active, 382 Activity ≤ 1 µM, 490 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
In Vitro AMPK Activation Assay from US Patent US9527839: "Benzimidazole tetrahydropyran derivatives"
Assay data:25 Active, 25 Activity ≤ 1 µM, 25 Tested
Activation Assay from US Patent US9428501: "Bicyclic nitrogen-containing aromatic heterocyclic amide compound"
Assay data:19 Active, 1 Activity ≤ 1 nM, 19 Activity ≤ 1 µM, 19 Tested
In Vitro AMPK Activation Assay from US Patent US9290517: "Azabenzimidazole hexahydrofuro[3,2-b]furan derivatives"
Assay data:25 Active, 3 Activity ≤ 1 nM, 25 Activity ≤ 1 µM, 25 Tested
Enzyme-Linked Immunosorbent Assay from US Patent US9663496: "AMPK-activating heterocyclic compounds and methods for using the same"
Assay data:459 Active, 382 Activity ≤ 1 µM, 492 Tested
KinomeScan assay: inhibition of AMPK-alpha2
Assay data:1 Active, 108 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
AMPKalpha2(PRA2LGY1) Takeda global kinase panel
Assay data:1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, activity ≤ 1 µMRelated BioAssays by Target
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