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Inhibition of gamma secretase in human H4 cells expressing human wild type APP assessed as reduction in amyloid beta 1-42 level at 100 uM for 12 hrs by ELISA
Assay data:2 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of gamma secretase in human H4 cells expressing human wild type APP assessed as reduction in amyloid beta 1-40 level at 100 uM for 12 hrs by ELISA
Inhibition of gamma-secretase (unknown origin) assessed as inhibition of NICD cleavage
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of gamma secretase derived from human Hela cell membrane assessed as reduction in amyloid beta (1 to 40) production by ELISA
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of gamma-secretase (unknown origin) assessed as inhibition of Amyloid beta 42 production by cell-free assay
Inhibition of gamma-secretase (unknown origin) assessed as inhibition of Amyloid beta 40 production by cell-free assay
Inhibition of gamma-secretase (unknown origin) assessed as inhibition of Amyloid beta 40 production by cell-based assay
Inhibition of gamma-secretase in human H4 cells assessed as reduction in amyloid beta 42
Inhibition of gamma-secretase (unknown origin) assessed as decrease in Abeta42 levels
Assay data:2 Active, 2 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested
Modulation of gamma-secretase (unknown origin) assessed as decrease in free Abeta42 levels
Assay data:2 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested
Modulation of gamma-secretase (unknown origin) assessed as decrease in total Abeta42 levels
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Modulation of gamma secretase in HEK293 cells expressing APP-C99 assessed as decrease in Abeta42 levels incubated for 2 hrs by sandwich ELISA
Assay data:4 Tested
Modulation of gamma secretase in HEK293 cells expressing APP-C99 assessed as decrease in Abeta40 levels incubated for 2 hrs by sandwich ELISA
Modulation of gamma secretase in HEK293 cells expressing APP-C99 assessed as increase in Abeta38 levels incubated for 2 hrs by sandwich ELISA
Modulation of gamma secretase in HEK293 cells expressing APP-C99 assessed as increase in Abeta37 levels incubated for 2 hrs by sandwich ELISA
Modulation of gamma secretase in HEK293 cells expressing APP-C99 assessed as decrease in Abeta42 levels at 5 uM incubated for 2 hrs by sandwich ELISA
Assay data:2 Active, 16 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Modulation of gamma secretase in HEK293 cells expressing APP-C99 assessed as decrease in Abeta40 levels at 5 uM incubated for 2 hrs by sandwich ELISA
Modulation of gamma secretase in HEK293 cells expressing APP-C99 assessed as increase in Abeta38 levels at 5 uM incubated for 2 hrs by sandwich ELISA
Assay data:9 Active, 15 Tested
Modulation of gamma secretase in HEK293 cells expressing APP-C99 assessed as increase in Abeta37 levels at 5 uM incubated for 2 hrs by sandwich ELISA
Modulation of gamma secretase in HEK293 cells expressing APP-C99 assessed as decrease in Abeta42 levels at up to 10 uM incubated for 2 hrs by sandwich ELISA
Assay data:1 Tested
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