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Inhibition of PRMT8 (unknown origin) incubated for 15 mins measured after 60 min by AlphaLISA assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryRelated BioAssays by Target
Selectivity interaction (Methyltransferase panel (Scintillation proximity assay (SPA))) EUB0000212b PRMT8
Assay data:1 Tested
Selectivity interaction (Methyltransferase panel) EUB0000196bCl PRMT8
Selectivity interaction (HMT panel) EUB0000194b PRMT8
Selectivity interaction (Protein methyltransferase panel (activity assay)) EUB0000211b PRMT8
Affinity Biochemical interaction (Scintillation proximity assay (SPA) ) EUB0000034d PRMT8
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition of human full length recombinant his-tagged PRMT8 (61 to 394 residues) using histone H4 as substrate incubated for 20 mins in presence of [3H]-SAM by radioisotope-based filter assay
Assay data:7 Active, 8 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of N/C-terminal His-tagged PRMT8 (61 to 394 residues) (unknown origin) expressed in Escherichia coli at 1 uM using 3H-SAM as a substrate relative to control
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of human recombinant full length N and C-terminal his-tagged PRMT8 (61 to 394 residues) expressed in Escherichia coli at 50 uM using GST-GAR as substrate by scintillation/filter plate assay relative to control
Inhibition of human recombinant full length N and C-terminal his-tagged PRMT8 (61 to 394 residues) expressed in Escherichia coli at 10 uM using GST-GAR as substrate by scintillation/filter plate assay
Inhibition of PRMT8 (unknown origin) by scintillation proximity assay
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of PRMT8 (unknown origin) at 1 to 10 uM
Assay data:2 Tested
HMT Assay from Article 10.1038/nchembio.2304: "An allosteric PRC2 inhibitor targeting the H3K27me3 binding pocket of EED."
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
In Vitro Enzymatic Assay from Article 10.1111/cbdd.12881: "Discovery of selective protein arginine methyltransferase 5 inhibitors and biological evaluations."
Assay data:5 Active, 1 Activity ≤ 1 µM, 13 Tested
PRMT Biochemical Assays from Article 10.1021/acschembio.5b00839: "A Potent, Selective, and Cell-Active Inhibitor of Human Type I Protein Arginine Methyltransferases."
Assay data:3 Active, 1 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 3 Tested
Inhibition of PRMT8 (unknown origin) at 10 uM using SAM as substrate measured up to 960 mins by AlphaScreen microplate reader assay relative to control
Inhibition of recombinant human N-terminal and C-terminal His-tagged PRMT8 (61 to 394 residues) expressed in Escherichia coli using histone H4 as substrate at 10 uM by radiometric HotSpot assay relative to control
Inhibition of recombinant His-tagged human PRMT8 expressed in Escherichia coli BL21 (DE3) using biotin-labeled histone H4-20 peptide as substrate incubated for 8 mins in presence of [3H]-SAM cofactor by scintillation proximity assay
Assay data:1 Active, 5 Tested
Inhibition of PRMT8 (unknown origin) using biotin-labeled histone substrate assessed as residual activity at 50 uM in presence of [3H-Me]SAM by scintillation proximity assay relative to control
Assay data:24 Tested
Inhibition of PRMT8 (unknown origin)
Assay data:2 Active, 12 Tested
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